关联检验中的reference与risk/effect allele在关联检测中，reference allele（non-risk或non-effect）是效应估计的基准，与参考基因组中的ref/alt概念分离。早期研究中，minor allele常被作为reference allele，但现在，为了消除混淆，研究者倾向于保持与reference genome的统一。risk allele则是与疾病关联的allel...
在这里的概念再次改变,同样的reference allele,在与 risk/effect allele并列时,则指的是GWAS关联检测中的reference allele (non-risk 或者 non-effect),也就是效应量beta(或odds ratio)估计时的参考,概念上与上述参考基因组的ref与alt的组合无关,但为了保持统一性,近年来研究中关联检验的reference 也会与 reference...
在这里的概念再次改变,同样的reference allele,在与 risk/effect allele并列时,则指的是GWAS关联检测中的reference allele (non-risk 或者 non-effect),也就是效应量beta(或odds ratio)估计时的参考,概念上与上述ref与alt的组合无关,但为了保持统一性,近年来研究中关联检验的reference 也会与 reference genome保持一...
Correlation of effect size and minor allele frequency.Michael, StocksRebecca, DeanBjörn, RogellUrban, Friberg
Effect of minor allele frequency on the number of single nucleotide polymorphisms needed for accurate parentage assignment: A methodology illustrated using Atlantic salmonanimal breedingaquacultureminor allele frequencyparentageSalmo salarsingle nucleotide polymorphisms...
Effect of minor allele frequency on the number of single nucleotide polymorphisms needed for accurate parentage assignment: A methodology illustrated using Atlantic salmonanimal breedingaquacultureminor allele frequencyparentageSalmo salarsingle nucleotide polymorphisms...
Tabangin M, Woo J, Martin L (2009) The effect of minor allele frequency on the likelihood of obtaining false positives . BMC Proc 3 ; Suppl 7 : S41 doi: 10.1186/1753-6561-3-S7-S41Tabangin M. E., Woo J. G., Martin L. J. (2009). The effect of minor allele frequency on the...
Woo, L.J. Martin, The effect of minor allele frequency on the likelihood of obtaining false positives. BMC Proc. 3(Suppl 7), S41 (2009). doi:10.1186/1753-6561-3-S7-S41Tabangin ME, Woo JG, Martin LJ (2009) The effect of minor allele frequency on the likelihood of obtaining false ...
Effect of the Minor C Allele of CNTN4 rs2619566 on Medial Hypothalamic Connectivity in Early-Stage Patients of Chinese Han Ancestry with Sporadic Amyotrophic Lateral Sclerosis [Corrigendum]AMYOTROPHIC lateral sclerosisALLELESGENEALOGY[This corrects the article DOI: 10.2147/NDT.S339456.]...
The risk allele C of the CNTN4 gene may therefore influence functional reorganization of the medial hypothalamus. The effects of the CNTN4 rs2619566 polymorphism may exist in the hypothalamic functional connectivity of patients with sALS.Wang, Yao...