Multiple regression analysis, with HOMA as the dependent variable, showed that BMI (β = 0.336, P < 0.001) and LDH (β = −0.239, P < 0.001), LDH-AUC (β = −0.296, P < 0.01) and postischemic LDH change (β = −0.321, P < 0.001) entered the equation. CONCLUSIONS. The ...
To our knowledge, the current study is the first that uses SEM to investigate the relationship between retinal microvascular and brain imaging markers of SVD. Whereas our retinal data reduction approach found most retinal measurements to be largely independent, i.e. not indicators of the same laten...
downstream pathological processes compared with vascular CMB, and (2) shed light on the mechanistic link between TBI and CMB, by examining whether TBI-related CMB occur as a direct result of the impact (eg, shear forces) or by initiating microvascular fragility leading to higher ri...
Microvascular brain pathology and late-life motor impairment. Neurology. 2013;80(8):712-718.PubMedGoogle ScholarCrossref 61. Buchman AS, Yu L, Wilson RS, Boyle PA, Schneider JA, Bennett DA. Brain pathology contributes to simultaneous change in physical frailty and cognition in old age. J...
7 = among the most extremely ill patients. CGI-improvement (change): 1 = very much improved since initiation of treatment; 2 = much improved; 3 = minimally improved; 4 = no change from baseline; 5 = minimally worse; 6 = much worse; 7 = very much...
These mediators can be activated by metabolic inflammation and microvascular disorders and may further cause damage to the white matter and impair cognitive function. These alterations can result in serious changes in cognitive abilities. The association between cognitive changes and metabolic syndrome has...
whereas higher doses of caffeine may impair memory acquisition. Biological effects of caffeine on brain function also included modulation of white matter lesions and/or microvascular ischemic lesions, and improved insulin sensitivity, so reducing the risk of type 2 diabetes, which is a strong risk ...
This does not exclude the possibility that more subtle types of vascular disease, such as microvascular damage or blood-brain barrier dysfunction, contribute to Aβ deposition.46Cerebrovascular disease is highly prevalent in the elderly population. In this study of clinically normal to mildly demented...
However, whether change of sleep duration itself or short sleep duration is the primary cause of higher MCI risk cannot be answered by our study. Our results based on longitudinal HNR Study data are in line with earlier cross-sectional analyses of the same cohort. Dlugaj et al. (2014)11 ...
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