Exercise Attenuates Chronic Unpredictable Mild Stress Induced Brain Microvascular Rarefaction In Obese Zucker Rat: Role Of Stat3 SignalingSkeletal muscle arterioles from obese Zucker rats (OZR) exhibit oxidant stress-based alterations in reactivity, enhanced alpha-adrenergic constriction, and reduced ...
Microvascular injury in a mouse model of mTBI To determine the vascular impairment in mTBI, we first compared the pathological changes and functional performances in an open-head severe TBI (sTBI) model with a close-head mTBI model, based on controlled cortical impact (Additional File 1: Fig. ...
Vascular Vascular NCD is a result of cerebrovascular diseases (e.g., infarcts, strokes, microvascular disease) Any age 0.2% in 65–70 years old, 16% in people >80 Common features include impaired complex attention and frontal-executive function. Other functional impairments may occur depending on...
Effect of 35% oxygen treatment on SDS score. Results are presented as mean ± SEM. Multivariate regression analysis: The mean ± SD changes in the scores from baseline to week four were − 5.7 ± 0.6 points in the oxygen-treated group and 1.6 ± 2.2 in the cont...
These mediators can be activated by metabolic inflammation and microvascular disorders and may further cause damage to the white matter and impair cognitive function. These alterations can result in serious changes in cognitive abilities. The association between cognitive changes and metabolic syndrome has...
We used changes of sleep duration between T1 and T0 as a further exposure of interest. Changes of sleep duration (sleep duration at T1 minus sleep duration at baseline) were grouped into three categories (≤ -1 hour, -1 hour to 1 hour (reference), ≥1 hour). As the PSQI was not...
Substantial evidence indicates that the replicative exhaustion of endothelial cells (ECs) and the functional alterations that occur during senescence contribute to the development of age-associated vascular disorders, such as atherosclerosis and chronic ischemic heart disease [1], [2], [3], [4], [...
it highlights monocyte extravasation as a possible early step in this disease. It is well-accepted that the microvascular anatomy places constraints on the inflammatory responses in the highly vascularized cerebral cortex. Leukocyte extravasation occurs through the penetrating post capillary venules, which...
Serum biomarkers are promising tools for evaluating patients following traumatic brain injury (TBI). However, their relationship with diffuse histopathology remains unclear. Additionally, translatability is a focus of neurotrauma research, however, studi
‘bland’ food. While hungry controls had lower c-Fos IR in key feeding-related areas than their ad libitum-fed counterparts, in hungry VPAs c-Fos was unchanged or elevated compared to the fed ones. The lack of changes in expression of feeding-related genes upon deprivation in VPAs was in...