Aging, neurodegenerative processes and ischemic vascular mechanisms all contribute to cerebral structural changes as longevity increases and, interactively, may enhance in progressive cognitive decline, with a
Exercise Attenuates Chronic Unpredictable Mild Stress Induced Brain Microvascular Rarefaction In Obese Zucker Rat: Role Of Stat3 SignalingSkeletal muscle arterioles from obese Zucker rats (OZR) exhibit oxidant stress-based alterations in reactivity, enhanced alpha-adrenergic constriction, and reduced ...
Substantial evidence indicates that the replicative exhaustion of endothelial cells (ECs) and the functional alterations that occur during senescence contribute to the development of age-associated vascular disorders, such as atherosclerosis and chronic ischemic heart disease [1], [2], [3], [4], [...
Chen, S.et al.Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke. Terraneo, L. & Samaja, M. Comparative response of brain to chronic hypoxia and hyperoxia., 1914 (2017). Increased free radical production due to ...
We used changes of sleep duration between T1 and T0 as a further exposure of interest. Changes of sleep duration (sleep duration at T1 minus sleep duration at baseline) were grouped into three categories (≤ -1 hour, -1 hour to 1 hour (reference), ≥1 hour). As the PSQI was not...
These mediators can be activated by metabolic inflammation and microvascular disorders and may further cause damage to the white matter and impair cognitive function. These alterations can result in serious changes in cognitive abilities. The association between cognitive changes and metabolic syndrome has...
Vascular Vascular NCD is a result of cerebrovascular diseases (e.g., infarcts, strokes, microvascular disease) Any age 0.2% in 65–70 years old, 16% in people >80 Common features include impaired complex attention and frontal-executive function. Other functional impairments may occur depending on...
This may also suggest that in addition to its potential benefits for oxidative stress and chronic inflammation [68], upregulation of HSPs may also have positive effects on muscle growth and fiber type switching. Calcium and calcineurin, known as regulators of muscle remodeling and fiber type ...
our study demonstrates that morphological changes that are potentially indicative of abnormal/injured astrocytes correlate strongly with the degree of thalamic GFAP parenchymal accumulation, which, in turn, is marked by increased circulating GFAP levels (Fig.8). Such dynamics suggest that increased serum...
Besides, numerous studies have suggested that alterations in microvascular adaptability, represented by a reduction in cerebral vasoreactivity (CVR), are associated with neurodegeneration [6,21]. CBF has therefore been suggested as a biomarker of preclinical AD, since changes in brain perfusion are ...