Exercise Attenuates Chronic Unpredictable Mild Stress Induced Brain Microvascular Rarefaction In Obese Zucker Rat: Role Of Stat3 SignalingSkeletal muscle arterioles from obese Zucker rats (OZR) exhibit oxidant stress-based alterations in reactivity, enhanced alpha-adrenergic constriction, and reduced ...
We hypothesized that these associations would be weaker in individuals with TBI, given that TBI-induced CMB may result as a consequence of head trauma rather than underlying microvascular disease.21-24 Methods Participants Participants were recruited as part of the PREVENT Dementia progra...
66 Ultimately, these brain circuits shared by both cognition and motor-gait performance can be affected by aging, neurodegenerative, and microvascular mechanisms, providing a rationale to propose that dual-task gait testing may serve as a “brain stress test” to detect impending cognitive decline ...
Microvascular rarefaction (MVR), a loss of terminal arterioles and capillaries, is generally regarded as a pivotal pathophysiological process of hypertension in its early stage [4]. Early and effective detection of MVR is crucial for hypertensive management. However, the commonly used technique, ...
whereas higher doses of caffeine may impair memory acquisition. Biological effects of caffeine on brain function also included modulation of white matter lesions and/or microvascular ischemic lesions, and improved insulin sensitivity, so reducing the risk of type 2 diabetes, which is a strong risk ...
We investigated the relationship between BMI and the risk of progression to AD in subjects with MCI, as well as the effect of BMI on progression to AD depending on age, sex, cognitive intervention, and chronic diseases. Methods Three hundred and eighty-eight MCI subjects were followed for ...
What is microvascular ischemic brain disease? What is spastic hemiplegic cerebral palsy? What is chronic traumatic encephalopathy? What is the pathogenesis of epilepsy? How long does aphasia last after a stroke? What are pediatric neurological disorders? Does aphasia affect memory? What is congenital...
Chen, S.et al.Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke.J. Neuroinflamm.14, 1–12 (2017). Terraneo, L. & Samaja, M. Comparative response of brain to chronic hypoxia and hyperoxia.Int. J. Mol. Sci...
In addition to the association of sleep and beta amyloid mentioned above, animal models showed that neuronal activity as observed during extended wakefulness or chronic sleep restriction could lead to an increase in tau production64,65,66. However, it is also difficult to identify the directionality...
Vascular Vascular NCD is a result of cerebrovascular diseases (e.g., infarcts, strokes, microvascular disease) Any age 0.2% in 65–70 years old, 16% in people >80 Common features include impaired complex attention and frontal-executive function. Other functional impairments may occur depending on...