Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological cascade after TB
Exercise Attenuates Chronic Unpredictable Mild Stress Induced Brain Microvascular Rarefaction In Obese Zucker Rat: Role Of Stat3 SignalingSkeletal muscle arterioles from obese Zucker rats (OZR) exhibit oxidant stress-based alterations in reactivity, enhanced alpha-adrenergic constriction, and reduced ...
Vascular Vascular NCD is a result of cerebrovascular diseases (e.g., infarcts, strokes, microvascular disease) Any age 0.2% in 65–70 years old, 16% in people >80 Common features include impaired complex attention and frontal-executive function. Other functional impairments may occur depending on...
In addition to the association of sleep and beta amyloid mentioned above, animal models showed that neuronal activity as observed during extended wakefulness or chronic sleep restriction could lead to an increase in tau production64,65,66. However, it is also difficult to identify the directionality...
Ischemic brain lesions associated with hypertension (HTN). HTN induces atherosclerosis of major extracranial and intracranial arteries, which could lead to major infarcts. HTN causes both microbleeds and macrobleeds and is the main pathogenetic factor for small vessel disease responsible for lacunar ...
(CONTEC Medical Systems Co., Ltd.; Shanghai, China).Exclusion Criteria: An unstable psychiatric condition; a need for change in current psychiatric medication prescriptions; suicidal ideations or suicide attempts at the time of recruitment; drug abuse; acute or chronic respiratory disease; any ...
Aphasia: Aphasia can be a troubling and even frustrating condition in which a person has difficulty comprehending or expressing language. It typically results from a brain injury, such as a stroke or a trauma. Answer and Explanation:1 Mild aphasia is a loosely used term to describe cases of ...
Substantial evidence indicates that the replicative exhaustion of endothelial cells (ECs) and the functional alterations that occur during senescence contribute to the development of age-associated vascular disorders, such as atherosclerosis and chronic ischemic heart disease [1], [2], [3], [4], [...
Serum biomarkers are promising tools for evaluating patients following traumatic brain injury (TBI). However, their relationship with diffuse histopathology remains unclear. Additionally, translatability is a focus of neurotrauma research, however, studi
it highlights monocyte extravasation as a possible early step in this disease. It is well-accepted that the microvascular anatomy places constraints on the inflammatory responses in the highly vascularized cerebral cortex. Leukocyte extravasation occurs through the penetrating post capillary venules, which...