It is becoming increasingly evident that cerebral dysfunction and outcome after severe (i.e., Glasgow Coma Scale — GCS ≤ 8) head injury (SHI) are related, as a rule, not only to the initial structural injury to the brain, but also to a variety of secondary pathophysiological mechanisms,...
microvascular endothelial cellsin vitro(29). Finally, possibly acting via acetylation and methylation pathways, chronic hypoxia decreases global transcriptional activity (30). Thus, in preclinical fetal studies, chronic high-altitude hypoxia resulted in reduced histone acetylation and DNA methylation, fetal ...
Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study. Cardiovasc Diabetol. 2019;18(1):95. Article PubMed PubMed Central Google Scholar Shi W, et al. Value of triglyceride-glucose index for the...
Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy. Redox Biol. 2023;67:102906. Article PubMed PubMed Central CAS Google Scholar Yoshihara I, Kondo Y, Okamoto K, Tanaka H. Sepsis-associated muscle wasting: a comprehensive review...
Relative contributions of macrovascular and microvascular dysfunction to disease severity in falciparum malaria J Infect Dis, 206 (4) (2012), pp. 571-579 CrossrefView in ScopusGoogle Scholar [84] J. Hanson, S.W.K. Lam, S. Alam, R. Pattnaik, K.C. Mahanta, M. Uddin Hasan, et al. Th...
Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects study. Lancet Diabetes Endocrinol. 2017;5(4):271-279. doi:10.1016/S2213-...
Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. JAMA. 2014;311(22):2297-2304. doi:10.1001/jama.2014.5988ArticlePubMedGoogle ScholarCrossref 15. Johnson BL, Blackhurst DW, Latham BB, et al. Bariatric surgery is ...
VSA is considered unlikely if ischemic changes were absent on the ECG or the ECG was not performed during the attack and none of the previous conditions was present. (Adapted from JCS Joint Working Group4). According to the JCS guidelines, VSA is considered definite if the patient has ...
Severe cases of COVID-19 were frequently characterized by coagulopathy and microvascular injury, leading to organ dysfunction [151,191]. The expression of ACE2 in vascular endothelial cells probably contributes to the pathophysiology of microcirculatory pathological changes. The histopathology from three ca...
Alternatively the major events, amputation and death, that we recorded as primary outcome could be mostly brought about by macrovascular arterial disease, whereas endothelial damage is mostly related to microvascular disease. The present study has several limitations: firstly we only recorded all-cause ...