FUNCTIONAL POLARISATION OF MICROGLIAL CELLS AND NEUROGENESIS: EVIDENCE FROM IN VITRO MODELS 来自 ResearchGate 喜欢 0 阅读量: 6 作者: L Minghetti 摘要: Cyclooxygenase (COX) catalyses the first committed step in the synthesis of prostanoids, a large family of arachidonic acid metabolites comprising ...
Microglia are the primary innate immune system cells in the central nervous system (CNS). They are crucial for the immunity, neurogenesis, synaptogenesis, neurotrophic support, phagocytosis of cellular debris, and maintaining the CNS integrity and homeostasis. Invasion by pathogens as well as in CNS...
cells in the inflammation process of AD.Microglia can be activated by β-amyloid protein,this activation can cause further release of pro-inflammatory cytokines and toxicmediators that might induce inflammatory responses in AD patients′brain and might contribute to neuronal injury and death.On the ...
PhenotypeMicroglia - resident myeloid-lineage cells in the brain and the spinal cord parenchyma - function in the maintenance of normal tissue homeostasis. ... K Saijo,CK Glass - 《Nature Reviews Immunology》 被引量: 902发表: 2011年 Cannabinoid receptor type 2 activation induces a microglial anti...
et al. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 7, 483–495 (2010). This study reported a role for microglia in supporting adult neurogenesis through phagocytosis of apoptotic neuroprogenitor cells in the subgranular zone niche of the ...
Results Efficient adult hippocampal neurogenesis relies on the presence of CX3CR1, but is independent on the presence of CX3CR1 Newborn cells that are destined to become neurons, within a few hours after their genesis start to express the microtubule-associated protein doublecortin (DCX) [42]....
Using stem-cell-derived microglia-like cells, we tested transcription factors’ (TFs) ability to regulate microglial states. We determined AD-stage-specific expression changes, linked AD-risk genes with microglial states, and outlined potential regulatory pathways in AD progression. Our data provide ...
You might find these chapters and articles relevant to this topic. A modified high-yield method for primary culture of rat retinal microglial cells Xiaokun Han, ... Jing Zhuang, in Experimental Eye Research, 2022 Abstract Microglial cells are the main immune cells of the retina. The primary cu...
et al. Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci. 31, 149–160 (2006). Article CAS PubMed Google Scholar Hoshiko, M., Arnoux, I., Avignone, E., Yamamoto, N. & Audinat, E. ...
Adult hippocampal neurogenesisRetrovirusConnectivityExtracellular matrixMicroglia are immune cells that play a crucial role in maintaining brain homeostasis. Among the mechanisms of communication between microglia and neurons, the CX3CL1/CX3CR1 axis exerts a central modulatory role. Animals lacking CX3CR1...