An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue- and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, ...
Organ-on-a-chip models are created to recapitulate the structural, microenvironmental and physiological functions of human organs. Recently, bioprinting has been applied to fabricate organ-on-a-chip models owing to its ability to print multiple materials and cell types simultaneously with good spatial...
organ‐on‐a‐chipAmyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease affecting upper and lower motor neurons with no cure available. Clinical and animal studies reveal that the neuromuscular junction (NMJ), a synaptic connection between motor neurons and skeletal ...
The feasible application ofmicrofluidic tissue/organ-on-a-chip as an impersonator of oral tissues and organs:a direction for future research three-dimensional cell culture models have been developed.Microfluidic tissues/organs-on-chips(TOOCs)are new devices that have provided the opportunity to ......
Introduction Organ-on-a-chip systems have emerged as an enabling in vitro platform for drug screening by providing the biomimetic 3D microenvironments and dynamic cues that are typically lacking in conventional simplified cell cultures1. Individual organ models can be connected in the same manner in...
Previous organ-on-chip models make use of artificial membranes to separate two fluidic channels representing the parenchymal and the endothelial side of native barriers. However, artificial membranes disallow close cell association. During this study, a microfluidic chip, in which a temporary chitosan-...
This novel design represents a broadly applicable three-dimensional technique for fabricating an "organ-on-a-chip" that serves as a viable platform for tissue studies. Current methods of biological research rely on animal testing and two-dimensional tissue cultures, but fail to provide physiologically...
Organ-on-a-chip microfluidic devices are increasingly used as a promising platform in cancer research, with a focus on specific biological aspects of the disease. This review focusing on ovarian cancer and microfluidic application technologies in its diagnosis. Additionally, it discusses microfluidic ...
Barrier-free, open-top microfluidic chip for generating two distinct, interconnected 3D microvascular networks ArticleOpen access02 October 2024 A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature ...
Calcium carbonate nanoparticles stimulate cancer cell reprogramming to suppress tumor growth and invasion in an organ-on-a-chip system Article Open access 29 April 2021 A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+ breast cancer cells Art...