In vitro detection limits were 200 nM with efficiencies up to 156,000 theoretical plates. To demonstrate the capability of these devices to detect changes in neurotransmitter levels, the effects of a glutamate uptake inhibitor on glutamate basal levels was monitored in the striatum of a rat. To ...
In this context, microfluidic-based in vitro models of the blood–brain barrier (BBB) are of particular interest as they provide an innovative approach for conducting research related to the brain, including modeling of neurodegenerative diseases and high-throughput drug screening. Here, we present ...
In this gate model, the geometry was designed based on two T-junctions2. Figure2a shows the fluid flow behavior of the AND/OR logic gate. Starting from inputs\(A\)and\(B\), a synchronous train of bubbles is generated and conducted through the channels. The output branches are tagged as...
Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research The implementation of microfluidic devices within life sciences has furthered the possibilities of both academic and industrial applications such as rapid ... N Gupta,JR Liu,B Patel,... - 《Bioengineer...
Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer. Biomaterials 34, 4109–4117 (2013). Article CAS PubMed Google Scholar Allen, J.W., Khetani, S.R. & Bhatia, S.N. In vitro zonation and toxicity in a hepatocyte ...
Microfluidics and nanofluidics is a field of science that operates in the micrometer and nanometer scale. A microfluidic–nanofluidic device consists of components such as valves, pumps and mixers for manipulating and transporting the fluid at this...
In addition, it was shown that culturing epithelial cells in different 2D patterns and initialing EMT influences the spatial pattern of EMT [21]. Based on the influences of tissue geometry observed in these examples, it is important to develop in vitro models with improved physiologically relevant...
Microfluidic-based mixing methods have aroused increasing attention due to their tremendous potential in bio-related and materials science fields. Achieving mixing based on microscale devices, microfluidic-based mixing methods offer several advantages over their macroscale device-based counterparts, such as ...
Recently, tannin from Spatholobi Caulis (TTS) has been shown to have potent anticancer and antiproliferative characteristics in a few preliminary studies. This experiment used 3D microfluidic, flow cytometry, and gene chip technology to study the efficacy and mechanism of action of TTS, as well ...
This study provides compelling evident that microfluidic device and nanoscale AFM imaging-based investigations of biofilms can aid in the study of biofilm-related infectious diseases.doi:10.1007/s13206-014-8406-6DiCicco, MatthewNeethirajan, Suresh...