The two major gene families, class I and class II , encode two different types of MHC molecules , which are functionally specialized in displaying antigenic peptides either to CD8 + (MHC class I) or to CD4 + (MHC class II) T-lymphocytes. This dichotomy of antigen presentation reflects an...
蛋白酶体在抗原提呈细胞中参与对胞质中内源性抗原的酶解。 2.抗原加工相关转运物(transporters associated with antigen processing,TAP)基因 TAP为内质网膜上一个异二聚体分子,分别由TAP1和TAP2两个座位基因编码。TAP参与对内源性抗原肽的转运,使其从胞质溶胶进入内质网腔,并...
MHC基因的遗传及出现规律 单元型遗传共显性表达人群中的高度多态性：一个基因座位上存在多个 等位基因（allele）。指群体中不同个体在等位基因拥有状态上存在差别。连锁不平衡：指分属两个或两个以上基因座位的等位基因，同时出现在一条染色体上的几率高于随机出现的频率。单元型遗传 MHC基因在一条染色体上的组合称单元...
(1)经典MHC基因经典MHCI类相关基因HLA-A、B、C、经典MHCII类相关基因HLA-DP、DQ、DR(2)免疫功能相关基因编码补体成分的基因C2、C4A、C4B、Bf(III类区),抗原加工递呈相关基因LMP、TAP、HLA-DM、HLA-DO(II类区),非经典I类基因HLA-E、F、G(I类区),炎症相关基因TNF、HSP70(III类区),基因座位genelocus,指...
LMP又称 蛋白酶体 相关基因(proteasome-related gene),由LMP2和LMP7两个基因组成,其编码产物LMP(low molecular mass polypeptide or large multifunctional protease)与内源性抗原的处理有关。TAP为多肽转运体基因,包括TAP1和TAP2两个基因,其编码产物TAP(transporter of antigenic peptides)与抗原肽的转运有关。HLA...
基因家族(gene family),是来源于同一个祖先,由一个基因通过基因重复而产生两个或更多的拷贝而构成的一组基因,它们在结构和功能上具有明显的相似性,编码相似的蛋白质产物。 几种重要的基因家族 (1)CYP450(cytochrome P450)基因家族 (2)MHC(major histocompatibility complex)基因家族 ...
其余为免疫功能相关基因(Immune function related gene),编码免疫功能相关抗原( Immune function related antigen)。 类基因:经典:B、C、A位点 非典型:E、F、G位点等 类基因:经典:DP、DQ、DR位点 非典型:DN、DM、DO位点等类基因: C4、C2、B因子、TNF、HSP70等 HLA复合体:人第六号染色体短臂6p21.31,长约...
evolution is influenced by complex interactions among population size, genetic variation, strength of selection, and gene flow, the overall goal in conservation genetics – maintenance of short-term local adaptations and preservation of long-term adaptive potential – might be a challenging task [32]...
gene-expression profile is controlled almost exclusively by a single master regulatory factor, which is known as the class II transactivator. As we discuss here, differential activation of the three independent promoters that drive expression of the gene encoding the class II transactivator ultimately ...