蛋白酶体在抗原提呈细胞中参与对胞质中内源性抗原的酶解。 2.抗原加工相关转运物(transporters associated with antigen processing,TAP)基因 TAP为内质网膜上一个异二聚体分子,分别由TAP1和TAP2两个座位基因编码。TAP参与对内源性抗原肽的转运,使其从胞质溶胶进入内质网腔,并...
Gene des ImnunsystemsSummary MHC-Genes: Do they influence the choice of partners via olfactory signals? Behavioral experiments in mice and humans suggest that genes of the major histocompatibilty complex (MHC) may be important for the differentiation of self and non-self during mate choice. While...
LMP又称 蛋白酶体 相关基因(proteasome-related gene),由LMP2和LMP7两个基因组成,其编码产物LMP(low molecular mass polypeptide or large multifunctional protease)与内源性抗原的处理有关。TAP为多肽转运体基因,包括TAP1和TAP2两个基因,其编码产物TAP(transporter of antigenic peptides)与抗原肽的转运有关。HLA复...
We have determined the nucleotide sequence of Q8/9 d gene of the BALB/c strain of mice, isolated from Steinmetz's cosmid library. As for all other class I genes of the Qa region, the Q8/9 d gene spans approximately 4.7 kilobases (kb) and consists of seven exons and six introns...
2.Ⅱ类基因(免疫应答基因)近年来对免疫应答的遗传控制进行了系统研究,证明运动对许多抗原的免疫应答是受常染色体显性基因控制,称此基因为免疫应答基因(immune response gene,Ir基因)。McDevitt等研究了小鼠对人工合成多肽体抗原的免疫应答,首先证明了Ir基因与H-2复合体呈连锁关系,定位于H-2K和H-2D座之间,因与免疫...
(1)经典MHC基因经典MHCI类相关基因HLA-A、B、C、经典MHCII类相关基因HLA-DP、DQ、DR(2)免疫功能相关基因编码补体成分的基因C2、C4A、C4B、Bf(III类区),抗原加工递呈相关基因LMP、TAP、HLA-DM、HLA-DO(II类区),非经典I类基因HLA-E、F、G(I类区),炎症相关基因TNF、HSP70(III类区),基因座位genelocus,指...
其余为免疫功能相关基因(Immune function related gene),编码免疫功能相关抗原( Immune function related antigen)。 类基因:经典:B、C、A位点 非典型:E、F、G位点等 类基因:经典:DP、DQ、DR位点 非典型:DN、DM、DO位点等类基因: C4、C2、B因子、TNF、HSP70等 HLA复合体:人第六号染色体短臂6p21.31,长约...
evolution is influenced by complex interactions among population size, genetic variation, strength of selection, and gene flow, the overall goal in conservation genetics – maintenance of short-term local adaptations and preservation of long-term adaptive potential – might be a challenging task [32]...
gene was expressed in the receptors' thymus with a transfection efficiency of 60.73%(56.04%—62.49%).Conclusion Ultrasound-guided intrathymic injection is a safe,effective and convenient way with high degree of target accuracy to perform gene transfection to thymus.This method might induce immune ...
The MHC gene organization of the two well-characterized frogs, X. laevis (and S. tropicalis), is representative of the 'primordial MHC' for jawed vertebrates because it is similar to that of other non- mammalian vertebrates in having separate but linked MHC class I and class II gene regions...