Type II alveolar cells (AT2s) are an additional nonhematopoietic cell type that have been reported to express MHCII at homeostasis in both rodents17,18,19,20,21,22and humans23,24,25,26,27. AT2s are epithelial cells present in the lung parenchyma, and their main physiologic functions are ...
53]. The variability of the MHC-molecules is correlated with the diversity of the T-lymphocyte receptors which in turn determine the disease and parasite resistance of an organism and thus may influence the long-term survival probability of populations [54–57]. The ...
Owing to its role in survival and reproductive success, immunogenetic diversity is an important predictor of individual quality and may be signaled via visual or chemical means. Our study provides support for the socially salient, chemical signaling of genetic quality in a strepsirrhine primate. Des...
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis J. Clin. Invest., 123 (2013), pp. 5009-5022 View in ScopusGoogle Scholar Cao et al., 2014 Q. Cao, X. Wang, M. Zhao, R. Yang, R. Malik, Y. Qiao, A. Poliakov, A.K. Yocum, Y. Li, W. Chen...
(Fig.4aand Supplementary Fig.6a). It was revealed that the expression of genes encoding CD4 and those involved in the regulation of lymphocytogenesis, includingIL7RandCCR7, was enriched in the CD4_Naive cluster. At the same time, CD16_NK and GZMK_CD8 expressed a clear cytotoxic signature,...
Survival curves were plotted using Kaplan-Meier estimates and compared by log-rank test. If the equality of variance tests indicated the group variances were not significantly different (p > 0.01) and the data was normally distributed, one-way ANOVA (Tukey’s multiple comparison test) was used ...