烈冰生物合作伙伴中国科学院上海营养与健康研究所王莹课题组和时玉舫课题组团队针对上述问题开展了系列研究,于近期在美国国家科学院院刊PNAS 期刊发表了题为:MHC class Ib–restricted CD8+ T cells possess strong tumoricidal activities的研究论文。烈冰生物参与了本研究中的单细胞测序和数据分析工作,下面我们一起了解...
MHC class Ia moleculesMHC class Ib-restricted CD8+ T cellsTbetThe importance of classical CD8+ T cells in tumor eradication is well acknowledged. However, the anti-tumor activity of MHC (major histocompatibility complex) Ib-restricted CD8+ T (Ib-CD8+ T) cells remains obscure. Here, we show...
Our understanding of the classical MHC class I molecules (MHC class Ia molecules) has long focused on their extreme polymorphism. These molecules present peptides to T cells and are central to discrimination between self and non-self. By contrast, the fu
MHC class Ib Antibody (130) is an IgG Armenian hamster monoclonal MHC class Ib antibody (also designated MHC class I-b antigen M3 antibody, M3 histocompatibility (H) antigen antibody, or M3 N-formylated peptide specific MHC class 1b antibody) that detects the MHC class Ib protein of mouse...
By contrast, the functions of the non-polymorphic MHC class I molecules (MHC class Ib molecules) have been elusive, but emerging evidence reveals that, in addition to antigen presentation, MHC class Ib molecules are involved in immunoregulation. As we discuss here, the subset of MHC class Ib ...
MHC class I molecules are composed of a polymorphic chain and a non-polymorphic invariant β chain (B2M) linked by a noncovalent interaction. MHC class I genes are categorized into classical (MHC class Ia) (HLA-A, -B, -C, see Glossary) or nonclassical (MHC class Ib) (HLA-E, -F, -...
产品编号: sc-18832 查看说明书 产品名称: MHC class Ib (130),hamster IgG anti-murine,IP/ .0 订购此产品 供应商: Santa 规格: 200ug 目录价: ¥:2980 库存状态: CAS编号: 应用范围: 种属来源: 相关信息: 保存条件: 说明书地址: 点击查看详细 打印此页 关闭此页 上一个:Integrin alpha ...
We recently identified a protective MHC class Ib-restricted CD8 T cell response to infection with mouse polyomavirus. These CD8 T cells recognize a peptide from aa 139-147 of the VP2 viral capsid protein bound to the nonpolymorphic H-2Q9 molecule, a member of the Qa-2 family of β(2)m...
Non-classical MHC class Ib molecules have attracted growing interest in recent years, especially because they interact with non-T-cell inhibitory or trigge... B Seliger,H Abken,S Ferrone - 《Trends in Immunology》 被引量: 231发表: 2003年 The 14-bp deletion polymorphism in the HLA-G gene ...
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