烈冰生物合作伙伴中国科学院上海营养与健康研究所王莹课题组和时玉舫课题组团队针对上述问题开展了系列研究,于近期在美国国家科学院院刊PNAS 期刊发表了题为:MHC class Ib–restricted CD8+ T cells possess strong tumoricidal activities的研究论文。烈冰生物参与了本研究中的单细胞测序和数据分析工作,下面我们一起了解...
MHC class Ib-restricted CD8+ T cellsTbetThe importance of classical CD8+ T cells in tumor eradication is well acknowledged. However, the anti-tumor activity of MHC (major histocompatibility complex) Ib-restricted CD8+ T (Ib-CD8+ T) cells remains obscure. Here, we show that CX3CR1-...
MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse polyomavirus infection MHC class Ib- restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse polyomavirus infection...
Enhanced presentation of MHC class la, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles:a promising strategy for tumor immunotherapy. Ma W,Smith T,Bogin V,Zhang Y,Ozkan C,Ozkan M,Hayden M,Schroter S,Carrier E,Messmer D,Kumar V,Minev B. Journal of Translational...
MHC class II–restricted presentation of exogenous antigens can easily be observedex vivoby EBV-transformed B cells (Nijenhuiset al., 1994) and melanoma cells (van Hamet al., 2000), implying that the MHC class II system “works” correctly and efficiently in these tumors. In addition, MHC...
T. MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2–M3)-restricted memory response. Nature Immunol. 5, 159–168 (2004). CAS Google Scholar Yeager, M., Kumar, S. & Hughes, A. L. Sequence convergence in the peptide-binding region of ...
identified in humans and mice, but their relative contributions to immunity is still uncertain. Unlike MHC class Ia-restricted CD8+T cells, MHC class Ib-restricted CD8+T cells are constitutively activated in naive animals and respond rapidly to infection challenge, hence filling the temporal gap ...
et al. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat. Biotechnol. 38, 199–209 (2019). Article PubMed PubMed Central Google Scholar Laumont, C. M. et al. Global proteogenomic analysis of human MHC class I-associated peptides ...
Hair bulb keratinocytes generate one of the few "immune privileged" tissue compartments of the mammalian organism by suppressing classical MHC class I (MHC Ia) antigens. Expression of non-classical MHC class I (MHC Ib) antigens in the follicle has been found, but only in its distal epithelium...
The proteasome is known to produce a substantial number of MHC class I–restricted epitopes from HIV-1 Nef in the context of different HLA hap- lotypes15,16. However, production of the HIV Nef epitope from amino acids 73-81 (HIV Nef (73-82)) that is restricted to both HLA-A3 and ...