MHC class I component β2-microglobulin (β2M) by cancer cells directly protected them from phagocytosis. We further showed that this protection was mediated by the inhibitory receptor LILRB1, whose expression
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Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin-superfamily - Banham, Colonna, et al. - 1999Banham AH,Colonna M,Cella M,Micklem KJ,Pulford K,Willis AC,Mason DY. Identification of the CD85 antigen as ILT2, an inhibitory MHC class I ...
(A) NK subsets defined by single inhibitory MHC class I receptors respond differently to 721.221 target cells. For this donor (HLA-C1, Bw4; KIR A1A1), the NK subsets bearing only LILRB1, KIR2DL1, or 3DL2 gave weak responses, such as the receptor-null subset, whereas NK cells bearing...
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Abstract Multiple lines of evidence have revealed a key role for inhibitory Fc gamma receptors class IIb (FcγRIIb) as negative modulators of innate and adaptive immune responses. Acquired and genetic factors regulate the expression of FcγRIIb receptors and modify their inhibitory potential. Recent...
CD94 / NKG2-A complex is the inhibitory receptor for the non classical MHC class I molecule HLA-E on human NK cells. To investigate CD69-initiated signal transduction pathways, and to evaluate CD94 / NKG2-A interference on CD69 triggering ability, we have generated transfectants ...
NK cells may co-express a distinct combination of receptors for MHC class I, whose repertoire varies in different individuals. These lymphocytes are predicted to acquire stochastically during maturation at least an inhibitory receptor for self MHC molecules that dominates under basal conditions over ...
LIR-1 is a class I MHC receptor related to natural killer inhibitory receptors (KIRs). Binding of LIR-1 or KIRs to class I molecules results in inhibitory signals. Unlike individual KIRs, LIR-1 recognizes many class I alleles and also binds UL18, a human cytomegalovirus class I MHC homolog...