MHC class I-deficient mice - Raulet - 1994 () Citation Context ...lin recognition (39). b2m 2 mice have been used as a model of CD81 T-cell deficiency to show that CD81 T cells either are required or are not required for protection against several infectious agents =-=(37)-=-. ...
MHC class I molecules are composed of a polymorphic chain and a non-polymorphic invariant β chain (B2M) linked by a noncovalent interaction. MHC class I genes are categorized into classical (MHC class Ia) (HLA-A, -B, -C, see Glossary) or nonclassical (MHC class Ib) (HLA-E, -F, -...
MHC Class II (I-A/I-E) -KO 品系名:C57BL/6Smoc-H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1 Smoc 品系状态:活体 | 目录号:NM-KO-18032 MHCII/B2m-KO(M-NSG,2) 品系名:NOD.Cg-PrkdcscidIl2rgem1MHCII/B2mem2Smoc 品系状态:下架 | 目录号:NM-KO-220541 ...
These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I. 应用领域:Immunodeficiency, immune system, transplantation research *使用本品系发表的文献需注明: MHC...
MHC Class I (H-2Db) Antibody (16-5999-82) in Flow Oncogene 2019 -Figure 6. CXCL14-mediated tumor suppression is abrogated by MHC-I knockdown in HNC cells. MOE/E6E7 CXCL14 cells were transduced with shRNAs directed to B2M and enriched for knockdown by FACS sorting for th...
Identification of CD8+ T cell epitopes is critical for the development of immunotherapeutics. Existing methods for major histocompatibility complex class I (MHC class I) ligand discovery are time intensive, specialized and unable to interrogate specific
Most tumor cells derive from MHC-I-positive normal counterparts and remain positive at early stages of tumor development. T lymphocytes can infiltrate tumor tissue, recognize and destroy MHC class I (MHC-I)-positive cancer cells (“permissive” phase I). Later, MHC-I-negative tumor cell ...
一、MHC-I类和MHC-II类基因 •HLA基因复合体位于人第6号染色体短臂；•HLA-I类基因集中在远离着丝点的一端，包括B、C、A三个亚区，其产物是HLA-I类分子；•HLA-II类基因复合体中位于近着丝点一端，由 DP、DQ、DR三个亚区组成，其产物是HLAII类分子。•HLA-Ⅲ类基因是编码补体和炎症相关分子基因...
主要组织相容性复合体( major histocompatibility complex,MHC) 是所有编码生物相容复合体抗原的基因群一种统称,表示可以进行MHC 基因家族(MHC classⅠ,class Ⅱ,class Ⅲ)编码而成分子,即MHA,的基因。MHA位于细胞表面,主要功能是绑定由病原体衍生的肽链,在细胞表面显示出病原体,以便于T-细胞的识别并执行一系列免疫...
Administration of human PBMCs into newly developed murine MHC class I- and class II-deficient NOG (NOG-dKO; NOG- Iab, B2m-double-knockout) mice showed sufficient engraftment of human immune cells with little sign of GVHD. Immunization with influenza vaccine resulted in an increase in influenza...