Assembly of complexes of class I MHC protein with the m4 protein of murine cytomegalovirusdoi:10.1016/1386-6532(99)90464-XDanielKavanaghSDOSJournal of Clinical Virology
Tapasin assembly surveillance by the RNF185/Membralin ubiquitin ligase complex regulates MHC-I surface expression Loading of antigenic peptides onto MHC-I is essential for adaptive immunity and requires the protein Tapasin. Here, the authors demonstrate that Tapasin levels are controlled by the RNF...
MHC class I molecules adopt a peptide-receptive conformation that is highly unstable until the peptide binds. To help stabilize them, MHC class I molecules are recruited into a multimericprotein complextermed the peptide-loading complex, in which stable MHC class...
Molecular Chaperones in MHC Class I and Class II Biosynthesis and AssemblyMHC class I and class II molecules are multisubunit receptors that require correct assembly of their individual subunits prior to cell surface expression. MHC class I molecules are comprised of a polymorphic transmembrane heavy ...
The assembly of MHC class I molecules is regulated by a multi-protein complex in the endoplasmic reticules (ER) termed the loading complex. Tapasin is sugg... KM Paulsson,PO Anderson,S Chen,... - 《International Immunology》 被引量: 56发表: 2001年 Structure and biosynthetic locus of the...
At the surface of all nucleated cells, major histocompatibility complex class I (MHC I) molecules (Fig. 1A,B) present peptide epitopes, resulting from cytosolic protein degradation, to cytotoxic T lymphocytes to enable the immune recognition of virally or malignantly transformed cells exposing non-...
Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-microglobulin,...
摘要: SynonymsSynonymsmajor histocompatibility complex class I antigen presentationDefinitionDefinitionMHC class I antigen presentation is the process by which antigen-presenting cells express foreign antigDOI: 10.1007/3-540-27806-0_976 被引量: 207 ...
The class I assembly pathway and formation of peptide loading complex (PLC) Current Opinion in Immunology 2008, 20:75–81 * * CONGENIC MOUSE STRAINS Strain A Strain A.B Selected Locus Intra-H2 Recombinant Congenic Mouse Strains Strain A Strain A.B Strain A.B (R1) Strain A.B (R2) K I...
To analyze the early events occurring during the folding and assembly of major histocompatibility complex class I antigens, we used a panel of P815 mouse mastocytoma transfectants expressing wild-type or mutant human leukocyte antigen (HLA)-Cw3 proteins. We observed that newly synthesized unassemble...