(b) nodule diameter 鈮 1 cm (n = 113), with a sensitivity of 80.6% and a specificity of 81.6% in validation cohort.Conclusions:This study suggests that the blood-based DNA methylation panel may provide the potential utility for early diagnosis of LC cases, which would promote early ...
Here, we developed a blood test of a novel panel of three established lung cancer methylation biomarkers for lung cancer detection. Short stature homeobox 2 gene (SHOX2), ras association domain family 1A gene (RASSF1A), and prostaglandin E receptor 4 gene (PTGER4) methylation was analyzed ...
Here, we developed a blood test of a novel three gene methylation panel and validated the diagnostic efficiency from a total of 351 subjects (197 controls, 154 cases). DNA methylation of short stature homeobox 2 gene ( SHOX2 ), ras association domain family 1A gene ( RASSF1A ), and ...
The methylation variation in the above sites may influence blood pressure, independent of genetic and early life environmental factors. More hypertension-discordant monozygotic twin pairs are needed to replicate these findings in the future to explore the stability of the results....
The immune system can monitor tumor development, and DNA methylation is involved in the body’s immune response to tumors. In this work, we investigate whether DNA methylation alterations in peripheral blood mononuclear cells (PBMCs) could be used as mar
CpG SiteChrGeneGene Expression: DNA MethylationGene Expression: Blood Pressure Traits FHSRSMeta-Analysis Coeffp ValueCoeffp ValueZ-ScoreFDR QTraitCoefft TestFDR Q cg23999170 1 TSPAN2 −1.38 2.7 × 10−14 −1.92 0.0062 −7.32 2.8 × 10−12 SBP 0.0048 11.36 5.0 × 10−29 DBP 0.005...
Our assay can be an effective blood test for patients where CRC risk is present but difficult to assess (e.g. mild symptoms with no CRC family history) and who would therefore not necessarily choose to go for further examination. This panel of markers, if validated, can also be a cost ...
and YTHDF2 in peripheral blood of RA patients were significant low compared to control patients [211]. YTHDF2 was significant decreased while IL-1β expression was increased in RA patients’ peripheral blood mononuclear cells [212]. These findings make it possible to early diagnose RA, even sk...
We assayed DNA methylation profiles of peripheral blood of individuals with idiopathic, heritable, or drug-induced PAH (n = 454, 429 after exclusions/quality control) and controls (n = 1226) using the Illumina Infinium MethylationEPIC BeadChip Kit, which covers over 850,000 methylation ...
The DNeasy Blood and Tissue Kit (Qiagen, Hilden Germany) was used for genomic DNA isolation. Total RNAs were isolated using Trizol reagent (Invitrogen, Karlsruhe, Germany). Of the 146 studied cases, 55 were spontaneous abortions (from 12 to 20 weeks gestation), 57 stillbirths (from 21 to ...