ReviewWhat is a cell type and how to define it? Author links open overlay panelHongkui Zeng 1Show more Add to Mendeley Share Cite https://doi.org/10.1016/j.cell.2022.06.031Get rights and content Under an Elsevier user license Open archiveSummary Cell types are the basic functional units ...
Small-cell lung cancer (SCLC) is a deadly cancer associated with smoke exposure that has neuroendocrine (NE) cell properties and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While most patients with SCLC respond initially to cytotoxic therapy, almo...
DNA methylationis a popular epigenetic mechanism that suppresses genes or turns them “off” by adding a methyl group to certain areas of DNA. This happens without any changes to the underlying genetic sequence, or ourgenotype. Based on past research,dietandexercisehave been closely linked to...
diagnostics Review A Pound of Flesh: What Cachexia Is and What It Is Not Emanuele Berardi 1,2,† , Luca Madaro 3,† , Biliana Lozanoska-Ochser 3, Sergio Adamo 3 , Lieven Thorrez 1 , Marina Bouche 3,* and Dario Coletti 3,4 1 Department of Development and Re...
What this means is that embryonic stem cells, unlike adult stem cells, can be coaxed into potentially forming almost any other of the hundreds of types of human cells. For example, while a blood stem cell can only make blood, an embryonic stem cell can make blood, bone, skin, brain, an...
There is a clear consensus on where the memory engram is stored—specific assemblies of synapses activated or formed during memory acquisition—and a substantial body of knowledge on how the engram is generated and maintained in the brain. However, knowing the building blocks and their properties ...
The everlasting vision of a predictive and preventive framework for disease assessment has pushed the medical sciences to search for new means to manage health care and translate basic research into clinical practice. However, as we dig deeper into the cell and disease mechanisms, the path is not...
1). The IHC test results show that the negative hMLH1 cannot directly indicate that there is no mutation in hMLH1, and the hMLH1 promoter needs to be tested to determine whether there is methylation or BRAF (v-RAF murine sarcoma viral oncogene homologB1) mutation, so as to exclude Lynch...
The proposed interaction of COVID-19, after entry, within the nervous system tissues, is sketched (Fig. 2). Neuro‑inflammation Neuro-inflammation is one of the major hallmarks associ- ated with a wide range of CNS disorders [20]. During infec- tion, IFNs and tumor necrosis factor-...
However, the magnitude of the interaction effects reported for FTO (or other common variants) is insufficient to war- rant the use of those data for clinical translation. Potentially reversible epigenetic changes in particular altered DNA methylation patterns could also serve as biomarkers of energy ...