参考文献: [1]Zhao F, Bai P, Xu J, et al. Efficacy ofcell-freeDNA methylation-based blood test for colorectal cancer screening in high-risk population: a prospective cohort study[J]. Molecular Cancer, 2023, 22: 157. [2]Imperiale T F, Ransohoff D F, Itzkowitz S H, et al. Multita...
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm eLife 2020.05.05 文章来源: Daniel W Belsky 点击文末“阅读原文”,即可查看本文献原文 研究背景 生物学基础...
[5] LUO H,WEI W,YE Z,et al.Liquid Biopsy of Methylation Biomarkers in Cell⁃Free DNA[J].Trends Mol Med,2021,27(5):482⁃500. [6] MARRUGO⁃RAMÍREZ J,MIR M,SAMITIER J.Blood⁃Based Cancer Biomarkers in Liquid Biopsy:A Promising Non⁃Invasive Alternative to Tissue Biopsy[J]....
3. 粪便DNA(结直肠癌检测) FOBT(fecal occult blood test)一直以来是结直肠癌(CRC)筛查的经典手段,一项临床研究比较无症状、≥50岁普危组人群粪便DNA与FIT检查,二种检查在同一标本中进行,所有参加者都进行结肠镜检查作为参考标准,共入组9989名参检人。粪便DNA检查包括分子分析与结直肠恶性肿瘤相关DNA突变和甲基化...
【摘要】随着生物医学的发展,DNA甲基化(DNA methylation)标志物在癌症诊断、治疗选择及预后评估中的重要性日益凸显。本专家共识旨在全面梳理DNA甲基化标志物的检测技术、临床应用及其在肿瘤管理中的潜力。此外,本共识将围绕DNA甲基化标志物...
[2] Chen, X., et al., Non-invasive early detection of cancer four years before conventional diagnosis using a blood test. Nat Communications, 2020. 11(1): p. 3475.
Every woman successfully treated for breast cancer lives with the knowledge that it could come back. New research published today in the journal Clinical Epigenetics may lead to a simple blood test to determine the risk of such recurrence, or the cancer
[5] Klein EA, Richards D, Cohn A, et al. Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set [published online ahead of print, 2021 Jun 23]. Ann Oncol. 2021;S0923-7534(21)02046-9. doi:10.1016/j.annonc.2021.05.806 ...
[5] Klein EA, Richards D, Cohn A, et al. Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set [published online ahead of print, 2021 Jun 23]. Ann Oncol. 2021;S0923-7534(21)02046-9. doi:10.1016/j.annonc.2021.05.806 ...
The same group further developed an assay to detect one of the candidates, Septin 9 (SEPT9), which was differentially methylated in CRC tissues [6] and can be sensitively and specifically detected in blood plasma [7, 8]. SEPT9 DNA methylation was analyzed in several case-control studies, ...