However, there is little data on survival outcomes and prognostic factors affecting survival in patients with metastatic breast cancer (MBC) in Africa. The study objective was to establish the survival of patients with MBC at a single tertiary health facility, the clinical an...
The AURORA US Metastasis Project was established with the goal to identify molecular features associated with metastasis. We assayed 55 females with metastatic breast cancer (51 primary cancers and 102 metastases) by RNA sequencing, tumor/germline DNA ex
Emerging studies have identified chronic psychological stress as an independent risk factor influencing breast cancer growth and metastasis. However, the effects of chronic psychological stress on pre-metastatic niche (PMN) formation and the underlying i
Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or
Breast cancer statistics Ca - Cancer J Clin, 69 (2019), pp. 438-451 2019 CrossrefView in ScopusGoogle Scholar [9] A.B. Mariotto, R. Etzioni, M. Hurlbert, L. Penberthy, M. Mayer Estimation of the number of women living with metastatic breast cancer in the United States Cancer Epidemi...
Here, we aimed to look at targeting Rac1 activity in a metastatic breast cancer setting during primary growth, local invasion, dissemination in the vasculature, and subsequent colonization of metastatic sites. Using 3D organotypic modeling of tumor-ECM interactions, fluid-flow-induced shear stress ...
The survival curves of adjusted by other prognostic factors (A: overall survival; B: breast cancer specific survival), stratified by different numbers of involved lymph nodes Full size image Descriptive statistics and survival analyses of axillary surgery types Baseline characteristics for different types...
Cell lines are widely-used models to study metastatic cancer although the extent to which they recapitulate the disease in patients remains unknown. The recent accumulation of genomic data provides an unprecedented opportunity to evaluate the utility of
et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med 30, 249–256 (2024). https://doi.org/10.1038/s41591-023-02677-x Download citation Received09 June 2023 Accepted01 November 2023 Published08 January 2024 Issue...
Triple-negative breast cancer—defined by the absence of oestrogen/progesterone receptors and human epidermal growth factor receptor 2 expression—is a complex and heterogeneous type of tumour characterised by poor prognosis, aggressive behaviour and lack of effective therapeutic strategies. The identification...