10516#Background:Breast cancer is the most commonly diagnosed malignancy in American women, with about 281,500 new reported cases this year, 3.8 million women living with an active or history of breast cancer, and a lifetime occurrence of 1 in 8 women in this nation. Racial disparities ...
The AURORA US Metastasis Project was established with the goal to identify molecular features associated with metastasis. We assayed 55 females with metastatic breast cancer (51 primary cancers and 102 metastases) by RNA sequencing, tumor/germline DNA ex
Article 10 January 2022 References Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2020. CA Cancer J. Clin. 70, 7–30 (2020). Article PubMed Google Scholar Caswell-Jin, J. L. et al. Change in survival in metastatic breast cancer with treatment advances: meta-analy...
Breast cancer can recur months to decades after an initial diagnosis and treatment. The mechanisms that control tumor cell dormancy remain poorly understood, making it difficult to predict which patients will recur and thus benefit from more rigorous scr
Here, we aimed to look at targeting Rac1 activity in a metastatic breast cancer setting during primary growth, local invasion, dissemination in the vasculature, and subsequent colonization of metastatic sites. Using 3D organotypic modeling of tumor-ECM interactions, fluid-flow-induced shear stress ...
The survival curves of adjusted by other prognostic factors (A: overall survival; B: breast cancer specific survival), stratified by different numbers of involved lymph nodes Full size image Descriptive statistics and survival analyses of axillary surgery types Baseline characteristics for different types...
2022, Pharmacology and Therapeutics Show abstract Progress and challenges of immunotherapy in triple-negative breast cancer 2021, Biochimica et Biophysica Acta - Reviews on Cancer Show abstract First-line atezolizumab plus nab-paclitaxel for unresectable, locally advanced, or metastatic triple-negative breas...
Because the combination of pembrolizumab (Keytruda), lenvatinib (Lenvima), and platinum-based chemotherapy showed early evidence of antitumor activity with a manageable safety profile in previously untreated patients with metastatic nonsquamous non–small cell lung cancer (NSCLC) examine...
Thus, metastases to the bone are at least as frequent in breast cancer as in lung cancer. The simplest explanation to the above presented statistics is that bone metastasis is not primarily seeded from the lung. Therefore we will have a separate direct dissemination paths from the primary to ...
Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33. Article PubMed Google Scholar Ciardiello F, Ciardiello D, Martini G, Napolitano S, Tabernero J, Cervantes A. Clinical management of metastatic colorectal cancer in the era of precision medicine. CA Cancer J Clin. 2022;72:372–...