Breast cancer, a highly fatal disease due to its tendency to metastasize, is the most prevalent form of malignant tumors among women worldwide. Numerous studies indicate that breast cancer exhibits a unique predilection for metastasis to specific organs including the bone, liver, lung, and brain. ...
A novel long non-coding RNA MIR4500HG003 promotes tumor metastasis through miR-483-3p-MMP9 axis in triple-negative breast cancer Wen-Der Lin , Chia-Hao Chang & Pei-Jung Lu Article 23 April 2024 | Open Access GATA4 regulates the transcription of MMP9 to suppress the invasion and mi...
Despite being the hallmark of cancer that is responsible for the highest number of deaths, very little is known about the biology of metastasis. Metastatic disease typically manifests after a protracted period of undetectable disease following surgery or systemic therapy, owing to relapse or recurrence...
- Statistics in Medicine 被引量: 141发表: 1998年 Identification of biomarkers in breast cancer metastasis by integrating protein-protein interaction network and gene expression data Identification of biomarkers for breast cancer metastasis is a well studied problem. Recently, several large-scale studies ...
The aim of the study was to define biological subtypes of breast cancer that have the propensity to metastasize to the leptomeninges and to assess factors influencing survival from detection of leptomeningeal metastatis (LM). One hundred and eighteen consecutive breast cancer patients with LM were ...
Metastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade locally, intravasate, and colonize distant tissues and organs, all steps that require tumor cell migration. The majority of studies on in
Breast metastasis from non-small cell lung cancer South. Med. J., 90 (10) (1997), pp. 1063-1064 Google Scholar Viani et al., 2020 G.A. Viani, C.V. Arruda, L.I. De Fendi Effectiveness and safety of reirradiation with stereotactic ablative radiotherapy of lung cancer after a first...
Breast cancer can recur months to decades after an initial diagnosis and treatment. The mechanisms that control tumor cell dormancy remain poorly understood, making it difficult to predict which patients will recur and thus benefit from more rigorous scr
New molecular insights challenge the traditional model of metastasis, and indicate that the metastatic capacity of breast tumours is an inherent feature, and not necessarily a late, acquired phenotype. Local breast cancer might have a 'non-metastatic, good-prognosis' stem cell of origin; metastasizin...
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis