Prognostic value of bone scan in patients with metastatic prostate cancer treated initially with androgen deprivation therapy. J Urol 2002; 168: 1423-6.Rigaud J, Tiguert R, Le Normand L, et al. Prognostic value of bone scan in patients with metastatic prostate cancer treated initially with ...
186Re-HEDP for Metastatic Bone Pain in Breast Cancer Patients Metastases in the skeleton are the most common of all bone neoplasms. The ultimate prognosis for patients suffering from bone metastases is poor. Therapy such as hormonal manipulation (for carcinomas of the breast and prostate) and cyt...
(See Prognosis and Treatment.) In patients with bone metastases, it is important to develop strategies that emphasize maintenance of function, including ambulation, for the remainder of these patients’ lives and to intervene when possible before a fracture occurs. The morbidity and mortality ...
Although prognosis is excellent in patients with early non-invasive disease, 5-year mortality rates with treatment exceed 80% once cancer has invaded the bone [6]. Normal bone processes, such as bone remodeling, produce a plethora of growth factors and cytokines that are strong ...
Bone histology at autopsy and matched bone scintigraphy findings in patients with hormone refractory prostate cancer: The effect of bisphosphonate therapy ... Bisphosphonates (BisP) are non-metabolized compounds with high bone affinity used in bone metastasis diagnosis and treatment. Currently, BisP are...
This striking effect is consistent with the broad spectrum of Runx2 properties in activating many genes in tumor cells that have already been established as indicators of bone metastasis in poor prognosis. Potential strategies to translate these findings for therapeutic applications are discussed....
The prognosis of metastatic bone disease is dependent on the primary site, with breast and prostate cancers associated with a survival measured in years compared with lung cancer, where the average survival is only a matter of months. Additionally, the presence of extraosseous disease and the ...
Many of the communicable diseases are under control now, but the incidence of chronic illnesses like cancer is going up. Most of the cancers tend to metastasize to bone. Contrary to the belief that the prognosis of patients with metastatic bone disease (MBD) as bad, the literature showed ...
Men with metastatic prostate cancer entered into trials designed to evaluate the impact of treatment on survival should be stratified based upon the EOD on the bone scan. This analysis also indicates that patients in the EOD IV category have a particularly poor prognosis and may be candidates for...
Once cancer cells spread to distant organs such as bone, the prognosis for the patient is generally poor. There is an urgent need to establish a greater understanding of the mechanisms whereby the bone marrow niche influences bone metastasis. Here we discuss insights into the contribution of the...