reported that the incidence of localized prostate cancer declined across age groups from 2012 to 2015, however, the incidence of distant metastatic disease increased gradually17. These metastases are associated with poor prognosis, bone pain, and pathological characteristics and indicate the incurability ...
Breast Cancer e-Tumor Boards: Case 4: ER+ mBC with Multiple Targetable Mutations Tools Drug Interaction Checker Pill Identifier Calculators Formulary Slideshow Advanced Prostate Cancer: Signs of Metastatic Disease Overview Practice Essentials Pathophysiology and Etiology Epidemiology Prognosis Show All ...
Predicting the incidence and prognosis of bone metastatic breast cancer: a SEER-based observational study. BioMed Res Int. 2020;2020:1–9. Google Scholar Xiao W, Zheng S, Yang A, Zhang X, Zou Y, Tang H, et al. Breast cancer subtypes and the risk of distant metastasis at initial ...
Prognosis of metastatic bone cancer and myeloma patients and long-term risk of medication-related osteonecrosis of the jaw (MRONJ): some critical pointsSupportive Care in Cancer -doi:10.1007/s00520-022-07214-zSpringer Berlin HeidelbergSupportive care in cancer : official journal of the Multinational...
process involving multiple steps and molecular events. Overall, it can be divided into several stages: changes in the pre-metastatic bone microenvironment, rise of osteotropic breast cancer cells, dormancy of cancer cells in the perivascular microenvironment, and the establishment of a vicious cycle ...
Many different drugs or drug combinations can be used to treat bone pain caused by bone cancer. These drugs may be used in combination with surgery, radiation, and other treatments which can affect the way the body handles medication, as well as cause their own side-effects. Prognosis ...
Bonemetastasisis a devastating diagnosis with a dismal prognosis. In particular, roughly 3 in 4 patients with advanced breast andprostate cancersdevelop incurable bone metastases (Society, 2017), withsurvival ratesof approximately 30% (Siegel et al., 2018). Once in bone,metastatic cancercells suppor...
As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoc
Thus the described technique may help identify patients with pancreatic cancer and at potentially high risk of early metastatic relapse. The results promise to be of important assistance for determining prognosis and the consequences in therapy of early stage pancreatic cancer. This is a preview of...
Bone metastasis is a lethal consequence of breast cancer. Here we used single-cell transcriptomics to investigate the molecular mechanisms underlying bone metastasis colonization—the rate-limiting step in the metastatic cascade. We identified that lymphotoxin-β (LTβ) is highly expressed in tumour ce...