Formation of the pre-metastatic bone microenvironment, rise of osteotropic breast cancer cells, dormancy of cancer cells in the perivascular microenvironment.aBreast cancer cells secrete miRNA, IL-1β, and extracellular vesicles to promote the formation of the pre-metastatic microenvironment.bThe tumor ...
International Urology and NephrologyFuse H, Mizuno I, Yokoyama T, Sakamoto T, Katayama T. Clinical study on prognosis of metastatic prostate cancer based on extent of disease on pretreatment bone scintigra- phy. Int Urol Nephrol. 1995;27:567-574....
miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4. Despite significant improvement in survival rates of patients with breast cancer, prognosis of metastatic disease is still dismal. Cancer stem-like cells (... H Okuda,F Xing,PR Pandey,... - 《Cancer Research...
Secondary or metastatic bone cancer spreads from a primary site to elsewhere in the body. It is more common than primary bone cancer and usually occurs later in life. Cancers that tend to spread rapidly to bone include those of the breast,lung,prostate,thyroid, andkidney. Symptoms include bone...
Upon arrival, cancer cells establish interactions with various bone-resident cells during the process of colonization. These interactions, to a large degree, dictate cancer cell fates at multiple steps of the metastatic cascade, from single cells to overt metastases. The bone microenvironment may even...
A 49-year-old male patient sought treatment at the National Cancer Institute (NCI) for pathological fracture in the left femur. Bone biopsy confirmed metastatic papillary carcinoma of thyroid origin; thus leading to total thyroidectomy. His final diagnosis was PTMC. Due to the fact that this was...
indicates that multiple myeloma-derived EV-rich amphiregulin (AREG).144and lncRUNX2-AS1.145may be critical factors that promote osteoclast activity or inhibit osteoblast activity. In addition, EVs derived from other tumors, such as osteosarcoma,146breast cancer,147non-small cell lung cancer,148and ...
Bone metastases in patients with metastatic renal cell carcinoma: Are they always associated with poor prognosis? J. Exp. Clin. Cancer Res., 34 (2015), p. 10 Google Scholar [7] R.J. Motzer, M. Mazumdar, J. Bacik, et al. Survival and prognostic stratification of 670 patients with advan...
such events play an important role in clinical staging and treatment protocols for early and accurate diagnosis of bone metastasis in breast cancer and for improving patient prognosis.The review summarizes the research status of imaging examination of bone metastasis in breast cancer and provides evidenc...
The recent progress in oncologic management of patients with localized cancer or metastatic disease has permitted a significant improvement in life expectancy. Nevertheless, bone metastases and their consequent skeletal-related events (SREs) are still associated with unfavorable prognosis and greatly affect ...