25,26On the one hand, nanoparticles can effectively improve the pharmacokinetic parameters and reduce the side effects of therapeutic or imaging agents in cancer treatment by site-specific drug delivery.27,28On the other hand, they can also target immune...
Bone cancer prognosis has improved with advancements in early diagnosis and treatment options. Get information about types, symptoms, stages, and treatment of bone cancer.
Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors. Despite significant improvements in therapy, the prognosis for cancer with bone metastasis is generally poor. Therefore, there is a great need for new ther... Y Shiozawa,KJ Pienta,RS Taichman - 《Clinical...
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[2]. However, the existing treatment methodologies for these bone-related diseases have many problems, such as poor therapeutic effects and continued poor prognosis [3]. Intriguingly, some researchers have proposed using stem cell transplantation to treat bone-related diseases due to their ...
The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion. Oncogene 2021, 40, 3929–3941. [Google Scholar] [CrossRef] [PubMed] Liu, F.; Zhang, H.; Song, H....
Bone cancer represents one of the most significant causes of bone defects, with reserved prognosis regarding the effectiveness of treatments and survival rate. Modern therapies, such as hyperthermia, immunotherapy, targeted therapy, and magnetic therapy, seem to bring hope for cancer treatment in ...
Additionally, energy-related metabolites such as lactate and glutamine are altered in bone cancer. These metabolites and pathways can be utilized to develop diagnosis, prognosis, and treatment procedures of bone diseases. 3.1. Osteoporosis Osteoporosis (OP) is the most known and common bone disease....
Figure 1. The vicious cycle of breast cancer bone metastases. Breast cancer cells secrete soluble factors, including parathyroid hormone-related protein (PTHrP), vascular endothelial growth factor (VEGF), interleukin (IL)-6, IL-8 and IL-11, which in the bone metastatic site act on osteoblasts ...
Additionally, energy-related metabolites such as lactate and glutamine are altered in bone cancer. These metabolites and pathways can be utilized to develop diagnosis, prognosis, and treatment procedures of bone diseases. 3.1. Osteoporosis Osteoporosis (OP) is the most known and common bone disease....