Primary bone cancer is rare. The majority of people who have cancer in their bones have secondary bone cancer. This means that cancer in their bones develops from the spread, also known as metastasis, from another cancer that developed elsewhere in their body. Bone cancer refers to the cases ...
Bone cancer represents one of the most significant causes of bone defects, with reserved prognosis regarding the effectiveness of treatments and survival rate. Modern therapies, such as hyperthermia, immunotherapy, targeted therapy, and magnetic therapy, seem to bring hope for cancer treatment in ...
2.2. Animal Models of Breast Cancer-Induced Bone Metastases Metastatic cells originating from advanced breast cancer frequently spread to bone as a secondary site in patients, leading to debilitating skeletal complications. Given the limited availability and difficulty of obtaining human bone metastatic sam...
Bone pain from cancer can be due to any type of cancer that forms or spreads in the bone. It may be due to primary bone cancer or secondary bone cancer. Secondary bone cancer, also known as metastatic bone cancer, is the one that has spread (metastasized) from another organ to the bon...
and metastatic OS lesions. These studies have ultimately defined various cellular components and processes associated with therapeutic resistance, metastasis, and overall prognosis.19,20,21,22,23,24,25,26Researchers have also highlighted the presence of various immune escape mechanisms within the OS TME...
(1999) Overexpression of p53 protein in primary Ewing’s sarcoma of bone: Relationship to tumour stage, response and prognosis. Br J Cancer 79: 1185–1189. [14] de Alava E, Antonescu CR, Panizo A, Leung D, Meyers PA, et al. (2000) Prognostic impact of P53 status in Ewing sarcoma....
Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival rate has only shown limited improvement, suggesting that existing ther
[2]. However, the existing treatment methodologies for these bone-related diseases have many problems, such as poor therapeutic effects and continued poor prognosis [3]. Intriguingly, some researchers have proposed using stem cell transplantation to treat bone-related diseases due to their ...
The expression of TGF-β in the tumor also provides an insight of its metastatic potential of the tumor. Increased circulating or urine TGF-β concentrations are also associated with a worse prognosis in prostate cancer patients [100]. Increased plasma TGF-β and CXCL1 are similarly associated ...
Some cancers are more serious than others, some are more easily treated than others (particularly if diagnosed at an early stage), some have a better outlook (prognosis) than others. So, cancer is not just one condition. In each case it is important to know exactly what type of cancer ha...