Furthermore, several molecules with neuroactive functions, including serotonin, gamma-aminobutyric acid, catecholamines, and acetylcholine, have been isolated from bacteria within the human gut. This review aims to explore the psychoactive metabolites reported to be produced by gut bacteria, particularly ...
Metabolites produced by gut bacteria and their urinary catabolites are the potential effectors of the gut-brain cross-talk and can be more directly translated into nutritional products or strategies. They can also serve as more direct and unequivocal biomarkers. Therefore, we first demonstrated that ...
The interaction between metabolites produced by gut bacteria and mitochondria in chronic disease, as shown in this figure. With the imbalance of intestinal flora, the intestinal tract undergoes a number of structural and functional changes including leaky gut syndrome, increased intestinal permeability, d...
The delicate balance between pro- and anti-inflammatory mechanisms, essential for gut immune homeostasis, is affected by the composition of the commensal microbial community. Regulatory T (Treg) cells expressing transcription factor Foxp3 play a key role in limiting inflammatory responses in the ...
Short-chain fatty acids (SCFAs), particularly acetate, propionate, and butyrate, are metabolites produced by gut microbiota fermentation of dietary fiber. SCFAs play a vital role in regulating metabolic processes, including glucose and lipid metabolism, inflammation, and gut barrier integrity [18,19,...
Here we identify human gut bacteria and corresponding enzymes that convert the secondary bile acid lithocholic acid into 3-oxoLCA as well as the abundant gut metabolite isolithocholic acid (isoLCA). Similar to 3-oxoLCA, isoLCA suppressed TH17 cell differentiation by inhibiting retinoic acid ...
Protein/Amino-acid metabolism. Gut bacteria produce a range of metabolites by synthesizing proteinogenic amino acids via protein fermentation11. These metabolites are known to exert beneficial or harmful effects on the host. VDRΔIEC mice showed increased levels of N1,N12-diacetylspermine, N('1...
aMicrobial metabolites. Gut bacteria modulate various host metabolic reactions, resulting in the production of metabolites such as bile acids, choline and short-chain fatty acids that are essential for host health131. Indeed, complex carbohydrates such as dietary fibre can be digested and subsequently...
Gut bacteria produce a range of metabolites by synthesizing proteinogenic amino acids via protein fermentation11. These metabolites are known to exert beneficial or harmful effects on the host. VDRΔIECmice showed increased levels of N1,N12-diacetylspermine, N(‘1)-acetylspermidine, N-acetylglutamate...
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science 359, 1151–1156 (2018). CAS PubMed Google Scholar Kovatcheva-Datchary, P. et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella. Cell Metab. 22, ...