Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibitionWeiwei Cui, Meng Guo, Dong Liu, Peng Xiao, Chuancheng Yang, Haidi Huang, Chunhui Liang, Yinghong Yang, Xiaolong Fu, Yudan Zhang, Jiaxing Liu, Shuang Shi, Jingjing Cong, Zili Han, ...
T cell differentiationT helper cellsBackground: High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in eliciting intestinal inflammation, however, the...
Here we show that formate, a metabolite produced by the CRC-associated bacterium Fusobacterium nucleatum, promotes CRC development. We describe molecular signatures linking CRC phenotypes with Fusobacterium abundance. Cocultures of F. nucleatum with patient-derived CRC cells display protumorigenic effects, ...
Together, our findings suggest that the gut microbial metabolite butyrate could promote antitumor therapeutic efficacy through the ID2-dependent regulation of CD8+ T cell immunity, indicating that gut microbial metabolites could be effective as a part of cancer therapy. Graphical abstract Download : ...
An additional subset of bacteria, such as Bifidobacteria, can also produce the same metabolite SCFAs via the pentose phosphate pathway [28]. Fig. 1 Synthesis and metabolism of SCFAs in the gastrointestinal tract. In the gut, the intestinal microbial metabolites of SCFAs, acetate, propionate and ...
5 to modulate human metabolism. Many gut metabolites are unique to the microbiota and can be classified as xenobiotics. Sometimes, crosstalk is not only limited to the host and the microbiota but also the members of the microbiota. Nieet al[12] found that a lumen-restricted metabolite 3-...
Chen T, Xie G, Wang X, Fan J, Qiu Y, Zheng X, Qi X, Cao Y, Su M, Wang X, Xu LX. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma. Mol Cell Proteom. 2011.https://doi.org/10.1074/mcp.M110.004945. ...
Metabolite profiling of human-originated Lachnospiraceae at the strain level. Imeta. 2022;1:4. Article Google Scholar Li A, Wang Y, Li Z, Qamar H, Mehmood K, Zhang L, Liu J, Zhang H, Li J. Probiotics isolated from yaks improves the growth performance, antioxidant activity, and ...
microbial transplants, probiotics, dietary interventions, and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the immunotherapy. Ongoing clinical trials are evaluating these approaches. This review presents the recent advancements in understanding the dynamic ...
Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics and assess the effects of human CSU fecal microbial transplantation, Klebsiella