此外作者还强调了通过递送益生元、益生菌和粪便菌群移植操纵肠道菌群对大脑健康的潜在治疗效力。这些方法可以有效治疗胃肠道疾病,虽然治疗神经和神经退行性疾病的适用性和疗效需要研究,但它们是有前景的工具,可以通过精确的微生物靶向治疗为疾病治疗和预防开辟尚未探索的途径。 论文ID 原名:Gut microbes and metabolites ...
On the other hand, the small molecules (metabolites) that are produced by microorganisms can diffuse through the mucin layer. As a result, the biochemical activities of our gut microbiota have a major impact on our physiology and health. Microbial metabolites not only determine the environment at...
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. However, it is unclear whether microbiota and metabolites have demonstrated changes at early PD due to the difficulties in diagnosis and identification of early PD in clini
南方医科大学余光创教授团队对上述问题进行了研究,并在Taylor & Francis旗下著名国际期刊Gut Microbes上发表研究文章:MMINP: A computational framework of microbe-metabolite interactions-based metabolic profiles predictor based on the O2-PLS algorithm。 作者:Wenli Tang, Huimin Zheng, Shuangbin Xu, Pan Li, Li...
Gut microbes and their metabolites mediate the ameliorative effects of melatonin on SD-induced cognitive impairment. A feasible mechanism is that melatonin downregulates the levels ofAeromonasand constituent LPS and upregulates the levels ofLachnospiraceae_NK4A136and butyrate in the colon. These changes...
(b) Cladogram generated using the LEfSe method showing the phylogenetic distribution of microbes associated with the MH and MU groups. Taxonomic levels of phylum, class, and order are labelled, while family and genus are abbreviated. Plots were depicted using LEfSe of Galaxy of the Huttenhower ...
Enterohemorrhagic Escherichia coli responds to gut microbiota metabolites by altering metabolism and activating stress responses 2023-03-23, doi: 10.1080/19490976.2023.2190303 如何生产具有目标功能的活菌群落? Gut Microbes——[9.434] ① 开发基于生态学和生物技术的微生物群落构建方法,选择9个菌株组成联合体,模...
and the distinct selection pressures shape the differential microbial xenobiotic biotransformation capacities. Often, the microbial biotransformation capabilities are different from that of host metabolism, shifting the pharmacokinetic and pharmacodynamic properties of xenobiotics and their associated metabolites. In...
我们的先前的研究表明,在这个队列中,ASD患者的肠道微生物群发生改变,代谢活动紊乱(Dan et al., Gut Microbes, 2020)。进一步进行系统的生物信息学分析,以确定SNV与肠道微生物群及其代谢物之间的关联。ASD单核苷酸多态性在先天免疫应答、蛋白糖基化过程和逆行轴突转运相关基因中显著富集。这些SNV还在微生物组组成和微...
来自中山大学的曾谷城、曾令婵、廖洪映等人发表在Gut Microbes上的一项研究发现,一种肠道细菌调节的长链非编码RNA(lncRNA CGB)通过与EZH2相互作用调节IFNg启动子H3K27三甲基化(H3K27Me3)表观遗传修饰参与结核分枝杆菌感染,揭示了以前未被认识到的肠道细菌-lncRNA-EZH2-H3K27Me3轴在提供结核病免疫保护方面的重要性,...