The importance of the gut-lung axis has become more evident following the identification of several gut microbe-derived components and metabolites, such as short-chain fatty acids (SCFAs), as key mediators for
Since the occurrence of motor deficits in PD patients initializes at the middle and/or late stages of PD, we aim to reveal potential diagnostic markers for early-stage PD disease before the onset of dyskinesia via the analysis of the gut microbes and metabolites of the α-syn mutant monkeys...
However, the microbial taxonomic diversity (including nonculturable and culturable microbes), functions, and metabolites related to Himalayan Griffons have not been fully explored. Methods In the present study, the 28 fecal samples of the Himalayan Griffons and 8 carrion samples were collected and ...
The gastrointestinal tract provides relatively stable living conditions for the gut microbiota, which performs nutritional, protective, and metabolic functions for its host. A stable gastrointestinal tract environment is vital for balance of gut microbes and maintaining the health of hosts. Although there...
Gut microbes and their metabolites mediate the ameliorative effects of melatonin on SD-induced cognitive impairment. A feasible mechanism is that melatonin downregulates the levels of Aeromonas and constituent LPS and upregulates the levels of Lachnospiraceae_NK4A136 and butyrate in the colon. These ...
Polyphenols, gut microbes and anti-inflammatory activity The polyphenols are catabolised in the colon by gut microbiota into its metabolites, which have greater bioavailablity and anti-inflammatory property than their precursors (Li, Christman, Li, & Gu, 2020). Colonic fermentation products such as...
1D). We propose that this approach is indeed better than the ones above for predicting the relation between microbes, metabolites, and the host condition. There are also more heuristic ML-based models that do not fit clearly into these categories, such as MiMeNet [60], and encoder-decoder-...
Meta-omics and evolving computational frameworks are leading to the prediction and discovery of more microbial metabolites and components that are relevant to immune system function. It is also important to probe how well-known microbial metabolites (such as SCFAs) and co-metabolites (such as polyami...
Changes in the gut microbiota and metabolites were studied using 16 S rRNA sequencing and mass spectrometry, respectively, and their contributions to neurological disorders were further evaluated by faecal microbiota transplantation in germ-free (GF) mice and probiotic administration in mice exposed to...
芬兰科学家Hany Ahmed在Gut Microbes期刊上发表的一篇关于微生物群代谢产物作为肠道和大脑双向交流的驱动因素的研究中(Microbiota-derived metabolites as drivers of gut–brain communication)所构建的研究基础便是“胃肠道”和“大脑”具有双向交流的这一事实。 胃肠道系统中的菌群组成的改变与一系列神经发育、神经退行性...