Gut microbial metabolites improve chemotherapy efficacy via regulating CD8+ T cells • The SCFA butyrate directly boosts the antitumor CD8+ T cell response via ID2 • ID2 regulates the function of CD8+ T cells through IL-12 signaling • Butyrate supplementation improves the antitumor therapy ...
Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics and assess the effects of human CSU fecal microbial transplantation,,, and metabolites in vivo. CSU gut microbiota displays low...
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity. Cell Metab. 33, 988–1000 (2021). Bultman, S. J. Molecular pathways: gene–environment interactions regulating dietary fiber induction of proliferation and apoptosis via butyrate for cancer ...
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity through the ID2-dependent regulation of CD8 T cell immunity, indicating that gut microbial metabolites could be effective as a part of cancer therapy.doi... Y He,L Fu,Y Li,... - 《Ce...
zone and IL-10 and negatively correlated with the latency and path length to reach the platform, TNF-α, IL-6, and LPS (Fig.6A). Thus, the gut microbial-mediated effect of SD or Mel may be correlated with its effect on regulating the potential of microbial metabolites (LPS and butyrate...
Although Trp is the least abundant amino acid in protein and cells, it is a biosynthetic precursor of a large number of microbial (Alkhalaf and Ryan, 2015) and host metabolites. The ability of specific bacteria to produce Trp has been known for a century and has been significantly exploited...
Overall,L. plantarumgrowth showed a similar trend across the two evolutionary setups. In the mouse diet, we found that the microbial load increased extremely fast, as it shifted from the initial inoculum of 102total CFU/mL to 3.34 × 108CFU/mL in less than 24 h (Fig.1B). Such a grow...
We additionally examined which genera are shared between datasets, to facilitate specific analysis of contributors to well-predicted metabolites. Out of 85 unique, none-rare genera found across all datasets, 55 (65%) were shared between 3 or more datasets (Additional file 3: Figure S1B). Pair...
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat. Commun. 6, 6734 (2015). CAS PubMed Google Scholar Tremaroli, V. & Bäckhed, F. Functional interactions between the gut microbiota and host metabolism. ...
The existence of the gut microbiota, along with its nutritious SCFA metabolites, can facilitate the growth of intestinal epithelial cells and regulate their differentiation and repair17,18,19. The intestinal barrier is the sole gate where entry of the gut microbiota or metabolites into the blood ca...