Evidence from human studies suggests that the microbiota-derived succinate contributes to the host energy homeostasis. The obese individuals display increased circulating succinate concentrations, which could be attributed to those with obesity produce more gut microbiota-derived succinate as compared with ...
Malaria is caused byPlasmodiumspecies and remains a significant cause of morbidity and mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of specific bacteria to the risk of severe malaria is unknown. Here, multiomics approaches demonstrate that specific species...
However, the crosstalk between the gut microbiome and the host in relation to tumour cell metabolism remains largely unexplored. Here we show that formate, a metabolite produced by the CRC-associated bacterium Fusobacterium nucleatum, promotes CRC development. We describe molecular signatures linking CRC...
While the host genotype has been proven to affect microbiota, the effect of diet, specifically dietary fat, also plays an important role in determining bacterial composition. A high-fat-fed animal displays a significant shift in both bacterial and metagenomic profiles as compared to an animal on ...
to that in hypertension. The metabolism changes of host with pre-hypertension or hypertension were identified to be closely linked to gut microbiome dysbiosis. And a disease classifier based on microbiota and metabolites was constructed to discriminate pre-hypertensive and hypertensive individuals from ...
The early life gut microbiome is crucial in maintaining host metabolic and immune homeostasis. Though neonates with critical congenital heart disease (CCHD) are at substantial risks of malnutrition and immune imbalance, the microbial links to CCHD pathop
known to be beneficial to host metabolism. These species are constantly changing with age. We also isolated 2055 strains from these samples by large-scale in vitro culture, most of which were detected by metagenomics, with clear complementarity between the two approaches. We also screened an age...
The gut microbiome has a variety of effects on the intermediary metabolism of the host. One important function of the gut microbiome is bile acid (BA) metabolism. In humans, primary BAs are synthesized from cholesterol in the liver, and are then conjugated with taurine (T) or glycine. In ...
injury and the full phenotypic expression of the disease33,34,35,36. It is possible that the vertical transmission of butyrate or other metabolites via mother’s milk contributes to disease protection in offspring. Although we did not measure the metabolites in nursing mice, concentrations of ...
Here we use a combination of genetics and metabolic profiling to characterize a pathway from the gut symbiont Clostridium sporogenes that generates aromatic amino acid metabolites. Our results reveal that this pathway produces twelve compounds, nine of which are known to accumulate in host serum. All...