Transcriptome comparison between musk secretion and non-secretion seasons showed signi cant changes in the scent glands for 53 genes involved in fatty acid and cholesterol synthesis and metabolism regulatory pathways, which include fatty acid biosynthesis, elongation, and metabolism; steroid biosynthesis; ...
We performed gene set enrichment analysis (GSEA) using Hallmark Gene Sets from the Molecular Signatures Database (MSigDB) to identify different functional pathways within the molecular subtypes [22]. Evaluation of the tumor microenvironment and responses to immunotherapy The CIBERSORT algorithm (https:/...
In addition, GSEA identified various pathways commonly associated with three key DELMRGs. Moreover, the regulatory network of miRNA-TF for key DELMRGs was established. Finally, significant differences in immune cell levels and several pathways were identified between the two subclusters. Conclusion ...
from multiple avenues, such as automated text mining of scientific publications, computational predictions of interactions informed by co-expression patterns, conserved genomic contexts, and meticulously curated databases that document experimental interactions as well as established complexes or pathways. To...
Here, we present a protocol for analysing incorporation of the non-radioactive stable isotopes carbon-13 (13C) and nitrogen-15 (15N) into polar metabolites in central carbon metabolism and related pathways. Our platform utilizes selected reaction monitoring (SRM) with polarity switching and amide ...
1B). DEGs were particularly enriched in hypoxia-inducible factor 1 (HIF-1) signaling pathway and several metabolism-related pathways, according to functional analysis based KEGG database (Supplementary Table S2). These metabolism-related pathways included glycolysis/gluconeogenesis, biosynthesis of amino ...
As key mediators of MetS, metabolic adipokines such as leptin, lipocalin, and resistin regulate inflammation and bone metabolism through distinct or synergistic signaling pathways. Their modulation of inflammatory responses and bone remodeling processes plays a critical role in the pathogenesis and ...
Due to this enzymic inhibition, OA was reported to induce numerous alterations in relevant cellular physiological processes, including several metabolic pathways such as glucose uptake, lipolysis and glycolysis, heme metabolism, and glycogen and protein synthesis. In order to further understand the ...
In contrast, the high-risk patients were more associated with non-metabolic pathways. In summary, our study provides novel insight into metabolism-related genes’ roles in ccRCC.Similar content being viewed by others Better prediction of clinical outcome in clear cell renal cell carcinoma based on ...
Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and ...