Among energy metabolism-related pathways, BC exhibits enhanced glycolysis, tricarboxylic acid (TCA) cycle, pentose phosphate pathway (PPP), glutamate metabolism, and fatty acid metabolism activities. These pathways facilitate the proliferation, growth and migration of BC cells. The progression of BC is...
endothelial nitric oxide synthase.74,219Moreover, EET-induced angiogenesis also involves crosstalk with other AA metabolizing pathways as 11,12-EET induced the expression of COX-2 in endothelial cells via a PKA-cAMP-dependent pathway230and COX-2 protein shifted EET metabolism away from DHETs and ...
these acetylation events at TSS are significantly related to the expression of their target genes, many of which are involved in cancer-related pathways in the neuronally expressed developmentally down-regulated 4 (NEDD4)-dependent manner. Interestingly, H3 ubiquitination and NEDD4, GCN5, and histon...
MscL-G22S activation altered energy-related metabolic pathways Because the proteomic analysis has identified a significant association between MscL-G22S activation and energy metabolism-related processes in cultured SCs, we then investigated the effects of MscL-G22S activation on the energy-related metabol...
cardiovascular diseases (CVD), cancers, and inflammatory diseases. This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD ...
See all related content metabolism, the sum of thechemical reactionsthat take place within eachcellof a living organism and that provide energy for vital processes and for synthesizing new organic material. Living organisms are unique in that they can extractenergyfrom theirenvironmentsand use it to...
[41]. The trans-sulfuration pathway is related to the methionine cycle and regulates cellular redox homeostasis. Deregulation of this pathway generates an excess offree radicals, leading to damage to proteins and DNA. Normal cells are protected from oxidative damage byglutathione, a product of the...
Tumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. The Cancer Metabolism section will offer a solid framework to promote and disseminate innovative studies examining metabolic reprogramming in ca...
13. Kwapis, J. L. et al. Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. Nature communications 9, 3323 (2018). 14. McClung, C. A. How might circadian rhythms control mood? Let me count the ways. Biological psychiatry 74, 242-24...
Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. Genomics 1997 Feb 1;39(3):370-6 Gubin AN, Njoroge JM, Wojda U, Pack SD, Rios M, Reid ME, Miller JL Identification of the dombrock blood group glycoprotein as a polymorphic...