Summary of genes in the aromatic amine metabolism pathway used for pathway-based analysis of multi-study bladder cancer GWAS.Idan MenasheJonine D. FigueroaMontserrat GarciaClosasNilanjan ChatterjeeNúria MalatsAntoni PicornellDennis MaederQi Yang
The genetic factors underlying the variation in tramadol response are complex, and likely involve multiple genes involved in the metabolism, transport, and response to the drug, as well as receptors that are implicated in patients' pain perception and modulation. CYP2D6 plays a critical role in th...
Themetabolism ofpaclitaxeliscatalysed,inpart,bycytochromeP450isoenzymesCYP2C8 and3A4(seesection5.2).ClinicalstudieshavedemonstratedthatCYP2C8-mediated metabolism ofpaclitaxel,to6α-hydroxypaclitaxel,isthemajormetabolicpathwayinhumans. Concurrentadministrationofketoconazole,aknownpotentinhibitorofCYP3A4,doesnot ...
Iron absorption and metabolism Bone morphogenetic protein-SMAD signaling provides a key pathway of hepcidin activation, whereas the membrane-bound serine protease matriptase-2 and the ... GJ Anderson,DM Frazer,GD Mclaren - 《Current Opinion in Gastroenterology》 被引量: 262发表: 2009年 Local Proteas...
Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. The role of CYP3A4 in the major pathway of carbamazepine elimination is consistent with the number of inhibitory drug interactions associated with its ... BM Kerr,KE Thummel,CJ Wurden,... - 《Bioc...
Cytochrome P-455 nm complex formation in the metabolism of phenylalkylamines. 8. Stereoselectivity in metabolic intermediary complex formation with a serie... Aus den Ketonen (I) erhlt man über die Imine (III) die Amine (IV), die z-u den Aminen (V) gespalten werden. U. B. + PAULSEN...
Thus, although there appears to be a maximal dose level in tissues, there may be continued residual uptake from additional meals because of delays in absorption, recirculation, and metabolism. One participant hypothesized that, with multiple doses, there could be more accumulation of lycopene in ...
Gain a complete understanding of “The Most Important Thing” by Howard Marks from Blinkist. The “The Most Important Thing” book summary will give you access to a synopsis of key ideas, a short story, and an audio summary.
As a regulator of the Hh signaling pathway, HHIP is vital for embryonic lung development and is also involved in mature airway epithelial repair62. We hypothesize that the observed pleiotropic effects at this locus may be attributable to the HHIP gene and its broad influence on lung functionality...
Isolated isobutyryl- CoA dehydrogenase deficiency: an unrecognized defect in human valine metabolism. Mol Genet Metab 1998;65:264-71 Taniguchi K, Nonami T, Nakao A, Harada A, Kurokawa T, Sugiyama S, Fujitsuka N, Shimomura Y, Hutson SM, Harris RA, Takagi H. The valine catabolic pathway in...