Lipids are a heterogeneous group of compounds that are soluble in nonpolar solvents such as ether, chloroform, and benzene, and are completely immiscible in water. They are a major group of organic compounds found in living matter. Lipids are essential to the structure and function of membranes,...
Studies of cellular energetics have revealed important roles of metabolic pathways in determining cell fate and response to injury. Insights from 2017 into the mechanisms underlying these pathways might identify therapeutic targets to minimize injury and promote repair. ...
Secondary metabolism consists of metabolic pathways and products of metabolism that are not absolutely required for the survival of the plant. Secondary metabolism is responsible for many bioactive compounds used medicinally. Latest Research and Reviews Elevational microhabitats influence some endolichenic tr...
the glucocorticoid receptor (GR), GCs downregulate the expression of pro-inflammatory genes and upregulate the expression of anti-inflammatory genes. Metabolic pathways have recently been identified as key parts of both the inflammatory activation and anti...
We find that obesity deregulates gene expression networks, including lipid handling, metabolic pathways and AP1 transcription factor and inflammatory signaling, in an organ- and EC-subtype-specific manner. The transcriptomic aberrations worsen with sustained obesity and are only partially mitigated by ...
Section edited by Violena Pietrobon and Mia Stanic Tumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. The Cancer Metabolism section will offer a solid framework to promote and disseminate ...
Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways 癌性恶病质(Cancer cachexia)表现为脂肪组织和骨骼肌缺失引起的体重显著下降,这会降低患者对癌症治疗的耐受,影响他们的生活质量和生存期。由于调节子、信号传导和代谢通路发生了显著改变,癌性恶病质的治疗并不顺利。理解骨骼肌萎缩/肥大的保守分子机制,为...
In spite of their common hypersaline environment, halophilic archaea are surprisingly different in their nutritional demands and metabolic pathways. The metabolic diversity of halophilic archaea was investigated at the genomic level through systematic metabolic reconstruction and comparative analysis of four com...
48 Tryptophan (Trp) is an essential amino acid involved in the metabolic pathways for serotonin and subsequently melatonin and for nicotinamide adenine dinucleotide (NAD+) (Fig. 28.7). In the latter pathway, also known as the kynurenine pathway, tryptophan is first catabolized by indoleamine 2,3...
Can we develop non-toxic inhibitors of metabolic pathways with clinical efficacy? All cells in our bodies require oxygen and nutrients. Energy is constantly needed to perform cellular functions, from muscle contraction to neuronal communication. Nutrients, however, are not only required to produce ener...