the glucocorticoid receptor (GR), GCs downregulate the expression of pro-inflammatory genes and upregulate the expression of anti-inflammatory genes. Metabolic pathways have recently been identified as key parts of both the inflammatory activation and anti...
Iron is essential to many fundamental biological processes, but its cellular compartmentalization and concentration must be tightly controlled. Although iron overload can contribute to obesity-associated metabolic deterioration, the subcellular localization and accumulation of iron in adipose tissue macrophages ...
Section edited by Violena Pietrobon and Mia Stanic Tumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. The Cancer Metabolism section will offer a solid framework to promote and disseminate ...
Lipids are a heterogeneous group of compounds that are soluble in nonpolar solvents such as ether, chloroform, and benzene, and are completely immiscible in water. They are a major group of organic compounds found in living matter. Lipids are essential to the structure and function of membranes,...
Secondary metabolism consists of metabolic pathways and products of metabolism that are not absolutely required for the survival of the plant. Secondary metabolism is responsible for many bioactive compounds used medicinally. Latest Research and Reviews ...
NAD+ can be produced from four dietary precursors, including nicotinamide (NAM), nicotinamide riboside (NR), nicotinamide mononucleotide (NMN) and nicotinic acid (NA), through different metabolic pathways. Alternatively, the de novo synthesis pathway can convert the essential amino acid tryptophan to ...
Studies of cellular energetics have revealed important roles of metabolic pathways in determining cell fate and response to injury. Insights from 2017 into the mechanisms underlying these pathways might identify therapeutic targets to minimize injury and promote repair. ...
3、 1. Anabolic pathways 2. Catabolic pathways 3. Amphibolic pathway Metabolism - Overview Catabolism and Anabolism Three-stage reactions of Catabolism Metabolic Pathways 1. Metabolic pathways are irreversible (because they must be regulated) 2. Reaction conditions are mild 3. Highly conserved among ...
Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways 癌性恶病质(Cancer cachexia)表现为脂肪组织和骨骼肌缺失引起的体重显著下降,这会降低患者对癌症治疗的耐受,影响他们的生活质量和生存期。由于调节子、信号传导和代谢通路发生了显著改变,癌性恶病质的治疗并不顺利。理解骨骼肌萎缩/肥大的保守分子机制,为...
网络代谢通路;代谢途径