Objectives: Glucocorticoids (GCs) are one of the most widely prescribed anti-inflammatory drugs. By acting through their cognate receptor, the glucocorticoid receptor (GR), GCs downregulate the expression ofpro-inflammatorygenes and upregulate the expression of anti-inflammatorygenes. Metabolic pathways h...
Secondary metabolism consists of metabolic pathways and products of metabolism that are not absolutely required for the survival of the plant. Secondary metabolism is responsible for many bioactive compounds used medicinally. Latest Research and Reviews ...
Studies of cellular energetics have revealed important roles of metabolic pathways in determining cell fate and response to injury. Insights from 2017 into the mechanisms underlying these pathways might identify therapeutic targets to minimize injury and promote repair. ...
Lipids are a heterogeneous group of compounds that are soluble in nonpolar solvents such as ether, chloroform, and benzene, and are completely immiscible in water. They are a major group of organic compounds found in living matter. Lipids are essential to the structure and function of membranes,...
metabolic pathways and AP1 transcription factor and inflammatory signaling, in an organ- and EC-subtype-specific manner. The transcriptomic aberrations worsen with sustained obesity and are only partially mitigated by dietary intervention and weight loss. For example, dietary intervention substantially attenu...
网络代谢通路;代谢途径
NAD+ can be produced from four dietary precursors, including nicotinamide (NAM), nicotinamide riboside (NR), nicotinamide mononucleotide (NMN) and nicotinic acid (NA), through different metabolic pathways. Alternatively, the de novo synthesis pathway can convert the essential amino acid tryptophan to ...
Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways 癌性恶病质(Cancer cachexia)表现为脂肪组织和骨骼肌缺失引起的体重显著下降,这会降低患者对癌症治疗的耐受,影响他们的生活质量和生存期。由于调节子、信号传导和代谢通路发生了显著改变,癌性恶病质的治疗并不顺利。理解骨骼肌萎缩/肥大的保守分子机制,为...
Other sugars encountered in the diet are likewise transformed into products that are intermediates of central metabolic pathways.Lactose, or milksugar, is composed of onemoleculeofgalactoselinked to one molecule of glucose. Sucrose, the common sugar of cane or beet, is made up of glucose linked ...
the series of reactions that take a given starting material and synthesize certain molecules that will be used in othersyntheticpathways are similar, or identical, among all cell types. From a metabolic point of view, the cellular processes that take place in alionare only marginally different fro...