Post-translational modification of proteins with ubiquitin (ubiquitination) provides a rapid and versatile mechanism for regulating cellular signalling systems. Met1-linked (or 'linear') ubiquitin chains have emerged as a key regulatory signal that controls cell death, immune signalling, and other vital...
Post-translational modification of proteins with ubiquitin (ubiquitination) provides a rapid and versatile mechanism for regulating cellular signalling systems. Met1-linked (or ‘linear’) ubiquitin chains have emerged as a key regulatory signal that controls cell death, immune signalling, and other vita...
The interaction between ErbB-2 and Tid-1 was first described by Kim et al., who reported that exogenenous hTid-1 expression promotes the ubiquitination and degradation of ErbB-2 in human breast cancer cell lines and suppresses the in vitro and in vivo growth of ErbB2-dependent mammary ...
Internalization of receptors into MVBs is regulated in part by receptor ubiquitination, which provides a recognition motif for proteins of the endosomal sorting complex required for transport machinery, such as hepatocyte growth factor substrate 1 (Hrs1). Ubiquitination of Met and EGFR is required for...
Met1-linked ubiquitination in immune signalling. FEBS J 2014;281:4337-4350.Fiil BK, Gyrd-Hansen M. 2014 Met1-linked ubiquitination in immune signalling. FEBS J. 281, 4337-4350. (doi:10.1111/febs.12944)Fiil, B.K., and Gyrd-Hansen, M. (2014). Met1-linked ubiquitination in immune ...
Ubiquitination is an essential post-translational modification that regulates most cellular processes. The assembly of ubiquitin into polymeric chains by E3 ubiquitin ligases underlies the pleiotropic functions ubiquitin chains regulate. Ubiquitin chains assembled via the N-terminal methionine, termed Met1-...
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol Cell. 2013;50:818-30.Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M (2013) OTULIN restricts Met1-linked ubiquitination to ...
Mechanistically, hypoxia induces the interaction of AGO2 with LUBAC, the linear ubiquitin chain assembly complex, which co-localizes with miRNA-induced silencing complex and in turn catalyzes AGO2 occurring Met -linked linear ubiquitination (M1-Ubi). A series of biochemical experiments reveal that ...
The interaction between ErbB-2 and Tid-1 was first described by Kim et al., who reported that exogenenous hTid-1 expression promotes the ubiquitination and degradation of ErbB-2 in human breast cancer cell lines and suppresses the in vitro and in vivo growth of ErbB2-dependent mammary ...