A distinct combination of E3 ubiquitin ligases and specific chaperones is required to achieve each type of linkage-specific ubiquitination. In the nucleus, however, proteasomal degradation of misfolded proteins requires only K48-linked ubiquitin chains, and is thus independent of K11 specific ligases ...
Cell Death Dis UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer Related Products 67198-1-PBS CoraLite® Plus 488 UBE1 Mouse Monoclonal antibody CL488-67198
In the cytoplasm, proteasomal degradation of misfolded proteins requires tagging with mixed lysine 48 (K48)- and lysine 11 (K11)-linked ubiquitin chains. A distinct combination of E3 ubiquitin ligases and specific chaperones is required to achieve each type of linkage-specific ubiquitination. In ...
The K11-linked ubiquitination (K11ub) of M.tuberculosis-secreted protein Rv0222 by host ANAPC2 suppresses the TLR2/TRAF6/NF-κB-mediated expression of proinflammatory cytokine mRNAs (Il1b and Il12 p40), part of innate immunity, by facilitating the recruitment of SHP1/2 to polyubiquitinated (...
ubiquitin K63 or K11 chains are involved more typically in altering the function of signaling proteins. When one considers the potential effects of chain length, linkage position, multiple sites of ubiquitination on target proteins, mixed-linkage chains, and even branching of ubiquitin chains, an en...
dysregulation of protein degradation caused by ubiquitinated proteasomes can lead to the development of CRC. This paper will extensively discuss the impact of the key enzymes involved in ubiquitination, namely ubiquitin-conjugating enzyme E2, ubiquitin-linked enzyme E3 and DUB, on the progression of ...
Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage. Clin Cancer Res. 2017;23:1104–1116. doi:10.1158/1078-0432.CCR-16-1585 57. Wu X, Luo Q, Liu Z. Ubiquitination and deubiquitination of MCL1 in cancer: deciphering ...
Alternatively, the C-terminal glycine can be linked head-to-tail to the N-terminal methionine of another ubiquitin molecule, giving rise to a peptide bond [8]. The latter mode of ubiquitination is called M1-linked or linear ubiquitination [9], [10], [11], [12], [13]. Moreover, ...
For example, tripartite motif containing 71 (TRIM71), an E3 ligase that was inactivated by phosphorylation via protein kinase A, ubiquitinated pRb and accelerated its degradation in a K48-linked poly- ubiquitination fashion, which facilitated breast tumor progression [35]. Moreover, RNF123, a ...
www.nature.com/cr A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination Jiazhang Qiu1, 2, Kaiwen Yu3, Xiaowen Fei2, 4, Yao Liu2, Ernesto S Nakayasu5, Paul D Piehowski5, Jared B Shaw6, Kedar Puvar7, Chittaranjan Das7, Xiaoyun Liu3, Zhao-Qing Luo1, 2...