UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer Authors - Kanghua Xiao View Article Related Products UBE1 Mouse Monoclonal antibody 67198-1-Ig UBE1 Mouse Monoclonal antibody 67198-1-PBS UBE1 Rabbit Polyclonal antibody ...
A distinct combination of E3 ubiquitin ligases and specific chaperones is required to achieve each type of linkage-specific ubiquitination. In the nucleus, however, proteasomal degradation of misfolded proteins requires only K48-linked ubiquitin chains, and is thus independent of K11 specific ligases ...
ubiquitin K63 or K11 chains are involved more typically in altering the function of signaling proteins. When one considers the potential effects of chain length, linkage position, multiple sites ofubiquitinationon target proteins, mixed-linkage chains, and even branching of ubiquitin chains, an enormo...
The K11-linked ubiquitination (K11ub) of M.tuberculosis-secreted protein Rv0222 by host ANAPC2 suppresses the TLR2/TRAF6/NF-κB-mediated expression of proinflammatory cytokine mRNAs (Il1b and Il12 p40), part of innate immunity, by facilitating the recruitment of SHP1/2 to polyubiquitinated (...
multiple sites on a substrate (multiubiquitination). In addition, ubiquitin contains seven lysine residues that can be further ubiquitinated (polyubiquitination). Monoubiquitination and K63-linkage are normally implicated in sorting and degradation in the lysosome, whereas K48-, K11-linked chains and ...
www.nature.com/cr A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination Jiazhang Qiu1, 2, Kaiwen Yu3, Xiaowen Fei2, 4, Yao Liu2, Ernesto S Nakayasu5, Paul D Piehowski5, Jared B Shaw6, Kedar Puvar7, Chittaranjan Das7, Xiaoyun Liu3, Zhao-Qing Luo1, 2...
Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage. Clin Cancer Res. 2017;23:1104–1116. doi:10.1158/1078-0432.CCR-16-1585 57. Wu X, Luo Q, Liu Z. Ubiquitination and deubiquitination of MCL1 in cancer: deciphering ...
For example, tripartite motif containing 71 (TRIM71), an E3 ligase that was inactivated by phosphorylation via protein kinase A, ubiquitinated pRb and accelerated its degradation in a K48-linked poly- ubiquitination fashion, which facilitated breast tumor progression [35]. Moreover, RNF123, a ...
Co-IP analysis showed that scVHL specifically induced K63-linked ubiquitination of scIκBα, but not K27-linked ubiquitination (Figure 3J, K). In addition, scVHL did not regulate other types of scIκBα ubiquitination (data not shown). These findings indicate that scVHL activates the NF-...
In the cytoplasm, proteasomal degradation of misfolded proteins requires tagging with mixed lysine 48 (K48)- and lysine 11 (K11)-linked ubiquitin chains. A distinct combination of E3 ubiquitin ligases and specific chaperones is required to achieve each type of linkage-specific ubiquitination. In ...