K63 Di-Ubiquitin Chains (human) (rec.) (untagged) Chain (SBB-UP0072) is a recombinant protein produced in E. colii. It is important for ubiquitin/autophagy, cancer and proteasomal degradation research.
ubiquitin是泛素，是一种小的蛋白。真核细胞常用泛素来修饰蛋白。比如给一个蛋白加上一个或者一串儿泛素。泛素化这个过程需要三种酶来参与。泛素上面有个甲硫氨酸N端，还散布着七个赖氨酸。这些个地方都可能与目标蛋白形成化学键。你这里K指的是赖氨酸lysine。63是指泛素第63个氨基酸，正好是赖氨酸K。...
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The specificity of this K63-linked ubiquitinspecific monoclonal antibody was demonstrated using di-ubiquitin chains and with endogenously ubiquitinylated species in both cell lysates and intact cells. The antibody has been extensively characterised by ELISA, one-dimensional Western blotting, ...
Lauwers E, Jacob C, Andre B (2009) K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway. J Cell Biol 185: 493-502.Lauwers E, Jacob C, Andre B. K63-linked ubiquitin chains as a specific signal for protein sorting into the muti...
Catalog #: UBC-632 K63-linked Di-Ubiquitin Quantity:50 g Linkage specific di-Ub is a substrate for enzymes that cleave the isopeptide linkage between two ubiquitin molecules. It can also be us
leading to enhanced RIPK1 K63-linked ubiquitination and survival signal of Adult T-cell leukemia/lymphoma cells [72]. Moreover, cancer-related mutations alter CYLD structure and which disturb its binding capacity to K63 ubiquitin molecule. The absence of CYLD DUB activity enhances cancer-promoting...
or K63R Myc-Ub along with Flag-DYRK1A and/or HA-TRAF2. Enriched Flag-DYRK1A showed strong ubiquitin signal in the presence of WT Myc-Ub and K48R Myc-Ub (Fig.3Dlanes 6 and 7), but not in K63R Myc-Ub (Fig.3Dlane 8), and thus we verified that the ~120 kDa signal is in...
The RING E3 ligases, the major member of RNFs, induce translocation of ubiquitin molecules from E2-ubiquitin intermediates to the substrate [56]. It has been found that RNF8 promotes Twist activation by inducing its K63-linked ubiquitination, which facilitates progression of tumor [57]. Also, ...