间质表皮转化因子 (c-Mesenchymal-epithelial transition factor, c-Met)是受体酪氨酸激酶的一种,较早就被发现在肿瘤细胞的活动中起到重要作用。这个蛋白对于肿瘤研究领域来说并不陌生,早在2008年,Nature Review Drug Discovery就发表过一篇关于c-Met抑制剂的详细综述[1]。这么多年,涉及c-Met靶点的项目并不在少数,...
Epithelial to mesenchymal transition (EMT) is a phenomenon in which epithelial cells lose their cell to cell adhesion and detach from the base of the membrane. EMT is a fundamental process which occurs during tumor progression and metastasis. Cancer genomics is a complex network which involves a ...
Epithelial-to-mesenchymaltransition;Meta- staticgrowth;Embryonicsignalingpathways;Transcrip- tionfactors;Cancer Coretip:Thisreviewarticlediscussesthemechanistic regulationofembryonicsignalingpathwayswithaspe- cialfocusonepithelialmesenchymaltransition(EMT)- activatingtranscriptionfactorsincancerprogression viamodulatingthe...
triazolopyrazine c-Met inhibitors cancer (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) human cancers mesenchymal-epithelial transition factor (c-Met) inhibitor 引用走势 2015 被引量:3 站内活动 ...
(e.g., E-cadherin) and promote that of mesenchymal markers (e.g., N-cadherin, Vimentin) and extracellular matrix components, facilitating the transition to a mesenchymal phenotype[230]. Growth factors, such as transforming growth factor-beta (TGF-β), act as a potent inducer of EMT[231]...
Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition Epithelial-mesenchymal transition (EMT) occurs during embryogenesis, carcinoma invasiveness, and metastasis and can be elicited by transforming growth fact... S Thuault,U Valcourt,M Petersen,... - 《Journal of ...
Epithelial-mesenchymal transition (EMT) is able to drive metastasis during progression of multiple cancer types, including non-small cell lung cancer (NSCLC). As resistance to immunotherapy has been associated with EMT and immune exclusion in melanoma, it is important to understand alterations to T-...
junctions (TJ) and desmosomes while permitting cell-to-cell communication through gap junctions.8This cell adhesion property does not support migration in vivo despite epithelial cells can migrate in vitro after trypsinization. Transforming growth factor-β (TGF-β), activation (Figs.1,3), and or...
SDF-1/CXCR4 promotes epithelial–mesenchymal transition and progression of colorectal cancer by activation of the Wnt/β-catenin signaling pathway Stromal cell-derived factor 1 (SDF-1) and its receptor, CXCR4, play an important role in angiogenesis and are associated with tumor progression. This ...
© TheRockefellerUniversityPress,0021-9525/2000/01/173/15$5.00 TheJournalofCellBiology,Volume148,Number1,January10,2000173–187 http://.jcb173 EpithelialMesenchymalTransitionbyc-FosEstrogenReceptorActivation InvolvesNuclearTranslocationof -CateninandUpregulationof -Catenin/LymphoidEnhancerBindingFactor-1Transcrip...