World Health Organization (WHO) grade II meningioma is associated with a high rate of recurrence and poorer survival than in grade I. The reference treatment is surgery, which should be as complete as possible. Currently, in grade II, there are no recommendations for systematic adjuvant treatment...
Decisions regarding optimal management depend largely upon symptoms, size, anatomic localization, growth rate, extent of resection, tumor grade, edema, and prior treatment, recognizing that advances in molecular profiling are well underway. Although meningiomas are typically benign, grade 2 lesions carry...
Lastly, they combined PDGF-B;Nf2;CDKN2AB lesions and found an even higher tumor take rate of 79% (54–94%) with 33% grade 1, 47% grade 2, and 20% grade 3 (but the same applies here as with the above CDKN2A/B−/− in relation to the malignancy grade). Median survival was ...
transtentorial). Adjuvant radiation therapy is used in poor surgical candidates or in cases of incomplete surgical resection. Overall, there is a good 5-year survival of 80%. However, recurrences are frequent (20% of patients
The aggressive clinical course and short survival are consistent with both anaplastic meningioma and a high-grade sarcoma. Emergence of a high-grade sarcoma in a recurrent meningioma: malignant progression or collision tumor? More results ► Medical browser ? ▲ anaphylactic shock anaphylactin anaphy...
High-grade glioma IMPT: Intensity-modulated proton therapy IMRT: Intensity-modulated RT LGG: Low-grade glioma OARs: Organs-at-risk OS: Overall survival PBT: Proton beam therapy QOL: Quality of life RBE: Relative biological effectiveness RT: Radiation therapy WHO: World Health Organi...
Local control and overall survival in atypical meningioma: a retrospective study. Purpose: To evaluate local control and overall survival after primary surgery for patients with atypical meningiomas. Methods and Materials: From the Depar... LK Goyal,JH Suh,DS Mohan,... - 《International Journal ...
(MG) for primary analysis and DKFZ methylation subclass to confirm the molecular diagnosis of meningioma).e,f, Kaplan–Meier survival curves showing PFS of meningiomas based on WHO grade (e) and MG (f).g–h, OS of meningiomas used in our study based on classification by WHO grade (g) ...
Chordoid meningioma has been designated WHO grade 2 in the previous and current editions of WHO central nervous system tumor classi- fications. However, many patients had long progression free survival, and the majority of the tumor recurrences could be attributed to either incomplete resections or...
A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. ...