There were 635 WHO grade 1 meningiomas, 498 with GTR and 133 with STR, and 101 WHO grade 2 meningiomas with GTR. The median follow-up was 4.6 years, the local recurrence rate was 12.0% and the rate of death was 8.4%. The biomarker classified 51.5% of meningiomas as intermediate risk ...
Good outcome (85% 5-year survival) ▪ 20% recurrence rate ▪ Wide surgical excision with clear margins Meningiomacomprises ∼10% of ear and temporal bone tumors, affecting predominantly middle-aged patients (mean, 50 years). There is a 2:1 female to male ratio, and women tend to be...
e,f, Kaplan–Meier survival curves showing PFS of meningiomas based on WHO grade (e) and MG (f). g–h, OS of meningiomas used in our study based on classification by WHO grade (g) and MG (h). Inset shows the P values from the pairwise log-rank test between groups with Benjamini...
Grade 2 meningiomas are a real problem in therapeutic management because of their tendency to reoccur. The most effective treatment is surgery. The role of adjuvant radiotherapy in this disease is still disputed due to its uncertain effect on progression-free survival.To show that early adjuvant ...
Chordoid meningioma has been designated WHO grade 2 in the previous and current editions of WHO central nervous system tumor classi- fications. However, many patients had long progression free survival, and the majority of the tumor recurrences could be attributed to either incomplete resections or...
CDKN2ABlesions and found an even higher tumor take rate of 79% (54–94%) with 33% grade 1, 47% grade 2, and 20% grade 3 (but the same applies here as with the aboveCDKN2A/B−/−in relation to the malignancy grade). Median survival was greatly decreased to 54 days, and ...
Finally, a functional gene enrichment analysis of DMPs, focusing on potential gene overlaps, was performed using the Molecular Signatures Database (MsigDB) through Gene Set Enrichment Analysis (GSEA) developed by the Broad Institute40with a cut-off of FDR (False Descriptive Rate) q-value < ...
Meningiomas are the most common primary central nervous tumor, constituting more than one third of presentations, with a large proportion benign World Health Organization (WHO) grade I.1, 2 Although the survival prognosis of meningioma has been largely favorable after surgical resection, its symptoms...
Lastly, they combined PDGF-B;Nf2;CDKN2AB lesions and found an even higher tumor take rate of 79% (54–94%) with 33% grade 1, 47% grade 2, and 20% grade 3 (but the same applies here as with the above CDKN2A/B−/− in relation to the malignancy grade). Median survival was ...
A WHO Grade II tumor carries a 7–8-fold increased risk of recurrence, even after GTR, as well as a slightly higher rate of mortality (Perry, 2006). Aizer et al. (2015) demonstrated overall survival (OS) benefits from GTR of atypical and malignant meningiomas using SEER data. Although ...