Good outcome (85% 5-year survival) ▪ 20% recurrence rate ▪ Wide surgical excision with clear margins Meningiomacomprises ∼10% of ear and temporal bone tumors, affecting predominantly middle-aged patients (mean, 50 years). There is a 2:1 female to male ratio, and women tend to be...
e,f, Kaplan–Meier survival curves showing PFS of meningiomas based on WHO grade (e) and MG (f). g–h, OS of meningiomas used in our study based on classification by WHO grade (g) and MG (h). Inset shows the P values from the pairwise log-rank test between groups with Benjamini...
The differences between two groups were analyzed by Student's t-test, one-way or two-way analysis of variance (ANOVA). The log-rank test was used to calculate the statistical significance of the Kaplan–Meier survival curve. P < 0.05 was considered to have statistical significance. 2.29. ...
The NanoZoomer 2.0 digital image scanner (Hamamatsu Photonics, Japan) was used to digitize stained slides for subsequent semiquantitative assessment by two neuropathologists (MWN and JKP). We included tumors (positive tumor take rate) displaying specific meningioma morphology using HE staining. To corr...
Progression free survival of chordoid, otherwise grade 1 meningioma was comparable to non-chordoid WHO grade 1 meningioma (p = 0.75), and significantly better than chordoid WHO grade 2 meningioma (p = 0.019). Conclusion: the chordoid histology alone may not justify a universal WHO ...
The most commonly used, IOMM-Lee, shows a high tumor take rate in subgroup analysis for both orthotopic models 87% (95% CI 95–98%) and heterotopic models 94% (90–96%), and it shows median survival of 10–27 days in orthotopic models, depending on the number of cells. In general...
(heterozygousp53), however with a 91% rate of sarcomas/osteosarcomas over the course of a mere 165 days (median survival). A conditional homozygous lesion ofp53flox/−withNf2flox/−was also tested by the same group using the cell-specific prostaglandin D2 synthase (PDGS;Cre), which ...
(OS), and toxicities related to RT were considered as outcomes of interest. Differences between two cohorts were estimated by calculating odds ratios (OR) for LR rate and hazard ratios (HR) for survival outcomes with 95% confidence intervals (CIs) for meta-analysis, using R version 4.0.3 ...
The 3-year progression rate for these tumors, even after gross total resection and adjuvant radiation, is 59.2%, while the overall survival is 78.6%. The optimal management of anaplastic meningioma in the recurrent setting is not well defined, with almost no literature on the toxicity of re-...
Patients without atypical histology or behavior had a 15-year local control rate of 71%, contrasted with 54% for patients with atypical histology or behavior (p-bar = .0011). Univariate and multivariate analysis for cause-specific survival revealed that treatment group (SE vs others), histology...