Suppression of AURKA, in conjunction with erastin, yields significant enhancements in the prognosis of a murine model of meningioma. Our study elucidates an unidentified mechanism by which AURKA governs ferroptosis, and strongly suggests that the combination of AURKA inhibition and ferroptosis-inducing ...
(Grade III).3Owing to the invasion and recurrence of malignant meningioma, the estimated overall 10-year survival rate is onlŷ15%.4Over the last few years, an increasing attention has been paid to the molecular genetics of meningiomas.5Specific gene dysfunctions have been implicated in the ...
Treatment of the tumor and dural margin with surgery and sometimes radiation are cornerstones of therapy for meningioma. Molecular classifications have provided insights into the biology of disease; however, response to treatment remains heterogeneous. In this study, we used retrospective data on 2,824...
2 of these were previously diagnosed as atypical, 1 malignant and 1 transitional meningioma. Last 2 cases were diagnosed as meningeal sarcoma. Subsequently, 3 cases underwent radiotherapy and one received chemotherapy. However, it was later found that prognosis for sclerosing meningiomas was similar ...
Local recurrence rate, progression-free survival (PFS), overall survival (OS), and toxicities related to RT were considered as outcomes of interest. Differences between two cohorts were estimated by calculating odds ratios (OR) for LR rate and hazard ratios (HR) for survival outcomes with 95% ...
SURVIVAL rateTREATMENT effectivenessBRAIN tumorsPROGNOSISSURGICAL excisionRADIOTHERAPYBackground: Meningiomas are extra-axial primary neoplasms that frequently arise from arachnoid cap cells. Meningiomas account for around 33% of all primary brain tumours. Objective: The aim of the pre...
Of note, all SWI/SNF mutations were confined to the poor prognosis (C1) subgroup (Fig. 2c). C1 constituted a more diffuse group on PCA, distinguished from C2 mainly along the first principal component. We next retrospectively sought follow-up survival data from the time of first surgery, ...
Prognosis wise, only one case recurred. This case had atypical histology and high-grade molecular features including truncating NF2 mutation, 1p, 8p, 10, 14, 22q loss, and homozygous deletion of CDKN2A/B. Progression free survival of chordoid, otherwise grade 1 meningioma was comparable to ...
Keywords Meningioma · Prognosis · Recurrence-free survival · Somatostatin receptor · SSTR · Immunohistochemistry · Tissue microarray * Felix Behling felixbehling@yahoo.de 1 Department of Neurosurgery, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Hoppe‑Seyler...
Prognosis and Treatment ▪ Good outcome (85% 5-year survival) ▪ 20% recurrence rate ▪ Wide surgical excision with clear margins Meningioma comprises ∼10% of ear and temporal bone tumors, affecting predominantly middle-aged patients (mean, 50 years). There is a 2:1 female to male ...