Preoperative determination of tumor grade may be helpful in deciding the type of surgery and the rate of resection. Blood markers have been used to predict the rate of malignancy and prognosis of tumors in different regions, including the brain. The current study investigated the use of blood ...
Meningiomasoccur in three histologic grades: typical (WHO grade I), atypical (WHO grade II), and anaplastic (WHO grade III), according to the histologic features expressed. They reflect the tendency towards aggressiveness, mainly recurrence and malignant behavior (Perry et al 2007). In addition, ...
These also encompass the equally diverse low-grade gliomas (LGGs, WHO grade II) and anaplastic gliomas (WHO grade III). Although the prognosis of gliomas varies based on grade and molecular signature [1], among other factors, a common element of delivering radiation therapy (RT) to these ...
Meningiomas are the most common primary brain tumor of adults. The majority are benign (WHO grade I), with a mostly indolent course; 20% of them (WHO grade II and III) are, however, considered aggressive and require a more complex management. WHO grade II and III tumors are heterogeneous ...
Prognosis5-year survival, 70%.TypesGrade 1—Benign/typical• Angiomatous• Fibrous (fibroblastic)• Lymphoplasmacyte-rich• Meningiothelial• Metaplastic• Microcystic• Psammomatous• Secretory• Transitional (mixed)Grade 2—Atypical• Chordoid• Clear cell• OncocyticGrade 3—...
grade meningiomas, such as immune, inflammatory, and neuronal gene expression programs (Supplementary Fig.3c). These data are consistent with our integrated analysis of all tumor samples (Fig.1b, d), and suggest that alterations in chromosome structure underlie clonal transcriptomic and epigenomic ...
Uzum N, Ataoglu GA (2008) Histopathological parameters with Ki-67 and bcl-2 in the prognosis of meningiomas according to WHO 2000 classification. Tumori 94(3):389–397 Sandberg DI, Edgar MA, Resch L, Rutka JT, Becker LE, Souweidane MM (2001) MIB-1 staining index of pediatric meningiom...
Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal...
Additionally, forkhead box protein M1 (FOXM1) facilitated the transcription of AURKA. Suppression of AURKA, in conjunction with erastin, yields significant enhancements in the prognosis of a murine model of meningioma. Our study elucidates an unidentified mechanism by which AURKA governs ferroptosis, ...
grade I according to the 2007 World Health Organization (WHO) grading system1,2. Benign tumours are associated with improved patient survival; however, only 33% of meningioma patients exhibited no neurological deficits in a long-term follow-up3. This unfavourable prognosis necessitates the need to...