Markers for memory T cell subsets LineageNaïve (TN)Central Memory (TCM)Effector Memory (TEM)Tissue-resident Memory (TRM)Stem Cell-like Memory (TSCM) HumanCD3+and CD4+or CD8+CD45RA+CCR7+CD45RO-CD27+CCR7+CD45RA-CD45RO+CD62L+CD27+CCR7-CD45RA-CD45RO+CD62L-CD27-CD69+CD103+CCR7+...
All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratification. Here we show that several surface markers, ...
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are positioned throughout the body and not only protect...
Phenotypic and functional heterogeneity within the memory T-cell pool result in distinct memory T cell roles in response to secondary challenge [15, 16]. Central memory T cells (TCM) typically express the lymph node homing markers, CD62L (L-selectin) and CCR7 and exhibit extensive proliferative...
Table 1 Phenotypic markers of memory T cells Full size table Efficacy of memory T cells against tumors ACT of T cells with a naïve, Tscm or Tcm immunophenotypes has shown superiorin vivoefficacy in preclinical testing. Compared with known memory cell populations, Tscm cells display an increase...
Both vaccine and adoptive cell transfer immunotherapy protocols are influenced by T memory cell heterogeneity and it is important to be able to use a single method for identifying these functionally distinct subsets of T memory cells. iQue® High-Throu
Memory CD8+ T cells in many NLTs lack CD62L (Casey et al., 2012), the defining phenotype of a Tem cell. However, NLT-derived memory T cells also express many markers not shared by any circulating population of memory T cells within blood (Casey et al., 2012, Gebhardt et al., ...
To visualize whether mouse tumors were surveyed by memory T cells specific for acute viral infections, we established mouse models that contained antiviral CD8 + T cells bearing markers compatible with immunohistochemistry, which favored the use of an antiviral transgenic T-cell population bearing a...
On the basis of their surface markers, T lymphocytes are divided into subsets of "naive" and "memory cells". We have defined the interrelationship and rela... Tough,F D. - 《Journal of Experimental Medicine》 被引量: 2248发表: 1994年 IL-7 is critical for homeostatic proliferation and surv...
T cells not only induces characteristic patterns of surface markers and cytokine production but also has a maturational aspect that affects a cell's ability to survive, respond to secondary stimulation, and form long-term immune memory.do... Pawel,Muranski,P Nicholas,... - 《Blood》 被引量:...