Effector memory T-helper (Th)17 (Th17(EM)) cells are thought to be essential for inflammation in Th17-mediated diseases, but have not been studied in detail. To identify superior surface markers to isolate a homogeneous population of Th17(EM) cells from peripheral blood, CD4(+) T cells ...
Here, using magnetic beads and fluorescence-activated cell sorting, we extensively phenotype the Tck effector cells and conclude that effector function resides within the CD4+CD45RO+, CCR7-, CD49dhigh population, and that these cells are derived from the effector memory CD4+ T cells in resting...
IGRP206-214-specific T cells in the peripheral lymphoid tissue expressed markers of chronic Ag stimulation, and their numbers were stable after diagnosis of diabetes, consistent with their memory phenotype. IGRP206-214-specific T cells in NOD mice expand, acquire the phenotype of effector-memory T...
CD4T cells lacking the costimulatory molecule CD28 have been described both in elderly individuals and in chronic inflammatory disorders, one being rheumatoid arthritis (RA). We, in this study, provide a comprehensive characterization of cell surface markers on and function of such CD28CD4T cells, ...
Andreas P Russ6, Tullia Lindsten3, Jordan S Orange2, Ananda W Goldrath7,8, Rafi Ahmed4 & Steven L Reiner1 Two seemingly unrelated hallmarks of memory CD8+ T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. ...
CXCR3+effector memory T cells differentiated primarily towards PD1-CD45RA+effector-memory CD8 T cells. This population was clonally expanded and characterized by a high degree of TCR sharing with peripheral blood. In addition, the intra-tumoural presence of this population prior to treatment is as...
Immunological memory is an important characteristic of adaptive immune response and elucidation of its cellular basis is critical for vaccine exploration and disease prevention. Recent studies have shown that memory T cells could be divided into central memory T cells and effector memory T cells, which...
T-lymphocyte subsets in particular activated effector memory T cells and natural killer (NK) T cells have been suggested to play an important role in the pathogenesis of psoriasis.关键词:cytotoxic T cells memory effector T cells natural killer T cells spreading psoriasis ...
Purpose The profile of central (=T-CM) and effector (=T-EM) memory CD4(+) T cell subsets and the possible role as surrogate markers of protection is studied in the volunteers with history of cutaneous leishmaniasis (HCL).Methods Profile of T cell subsets based on CCR7/CD45RA expressions...
Terminally differentiated effector memory CD45RA+CD62L– CD8+ T cells were significantly decreased in RA patients, whereas the central memory CD45RA–CD62L+ CD8+ T-cell population was increased as compared with levels in healthy control individuals. Naïve and preterminally differentiated effector...