Effector memory T cells are associated with atherosclerosis in humans and animal models. J Am Heart Assoc 2012;1:27e41.Ammirati E, Cianflone D, Vecchio V, Banfi M, Vermi A, De Metrio M, Grigore L, et al. , Effector Memory T cells Are Associated With Atherosclerosis in Humans and ...
Unfortunately, donor T cells can attack nonmalignant host tissues and cause graft-versus-host disease (GVHD). We previously reported that donor CD4+ effector memory T cells (TEMs) do not cause GVHD but transfer functional T-cell memory. In the present work, we demonstrate in an MHC-...
CD4T cells lacking the costimulatory molecule CD28 have been described both in elderly individuals and in chronic inflammatory disorders, one being rheumatoid arthritis (RA). We, in this study, provide a comprehensive characterization of cell surface markers on and function of such CD28CD4T cells, ...
Andreas P Russ6, Tullia Lindsten3, Jordan S Orange2, Ananda W Goldrath7,8, Rafi Ahmed4 & Steven L Reiner1 Two seemingly unrelated hallmarks of memory CD8+ T cells are cytokine-driven proliferative renewal after pathogen clearance and a latent effector program in anticipation of rechallenge. ...
memory differentiation, while the KLRG1hipopulation represents terminally differentiated lymphocytes destined for death1. It should be appreciated, however, that these markers, while useful, do not fully capture the degree of heterogeneity of effector cells, as additional phenotypic and functional ...
Naïve CD8+ T cells can differentiate into effector (Teff), memory (Tmem) or exhausted (Tex) T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capacities and therefore therapeutic potential. The molecular...
Purpose The profile of central (=T-CM) and effector (=T-EM) memory CD4(+) T cell subsets and the possible role as surrogate markers of protection is studied in the volunteers with history of cutaneous leishmaniasis (HCL).Methods Profile of T cell subsets based on CCR7/CD45RA expressions...
In conclusion, we show that effector memory CD4(+) T-cells (CCR7(-)CD27(+)) respond specifically to the drug responsible for MPE and confirm previous data about the involvement of CCR10 in cell trafficking to the skin. 展开 关键词: allergy skin t cells chemokines cell trafficking ...
CD38 Bright Effector Memory CD8+ T Cell Populations Predict Acute Graft Versus Host DiseaseChronic allograft rejectionInduced protein 8-like 2Novel biomarkerTumor necrosis factorTumor necrosis factor-ainduced protein 8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the relationship ...
Markers of lymphocytes depletion after activation would be studied such as PD-1+, CTLA-4 + and TIM-3 + for CD4 + T cells. Markers of memory residence and function would be studied: CD103+, KLF6+, JUN+, JUN6+.