A higher proportion of early-differentiated Memory Stem (T) and Central Memory BM-T cells express multiple IR in relapsing patients than in CR patients. Exhausted BM-T cells at relapse display a restricted TCR repertoire, impaired effector functions and leukemia-reactive specificities. In 57 ...
The team treated human T cell lines with the HDAC inhibitor vorinostat and IL-21. With vorinostat relaxing the chromatin, IL-21-generated STAT3 activated CD28, resulting in expansion of T cells bearing the markers for central memory T cells. The main markers are CD28 and CD62L expression. A...
Incomplete CD4 restoration may be associated with a defective restoration of central memory CD4 T cells, a cell subset with a pivotal role in T cell homeostasis. 展开 关键词: immune reconstitution long-term HAART thymopoiesis DOI: 10.1093/jac/dkt245 被引量: 9 ...
Central memory CD4 T cells are associated with incomplete restoration of the CD4 T cell pool after treatment-induced long-term undetectable HIV viraemia.Central memory CD4 T cells are associated with incomplete restoration of the CD4 T cell pool after treatment-induced long-term undetectable HIV vira...
To characterize the replicative capacity of human central memory (T(CM)) CD4 T cells, we have developed a defined culture system optimized for the ex vivo expansion of Ag-specific CD4(+) T cells. Artificial APCs (aAPCs) consisting of magnetic beads coated with Abs to HLA class II and a ...
Despite the effective antiretroviral treatment (ART) of HIV-infected individuals, HIV persists in a small pool. Central memory CD4+ T cells (Tcm) make a major contribution to HIV persistence. We found that unlike HLA-DR, CD38 is highly expressed on the T
(A) The frequency of CD8β+ cells in BM, spleen, and blood of young adult C57BL6 mice. *p < 0.05 and **p < 0.01 versus BM (one-way ANOVA). Error bars show mean ± SEM. (B) Activation/memory markers on CD8β+ T cells in mouse BM and spleen. Cell frequencies among all CD8β...
Human central memory CD4 T cells are characterized by their capacity of proliferation and differentiation into effector memory CD4 T cells. Homeostasis of central memory CD4 T cells is considered a key factor sustaining the asymptomatic stage of Human Im
Purpose The profile of central (=T-CM) and effector (=T-EM) memory CD4(+) T cell subsets and the possible role as surrogate markers of protection is studied in the volunteers with history of cutaneous leishmaniasis (HCL).Methods Profile of T cell subsets based on CCR7/CD45RA expressions...
Memory CD8+ T cells are heterogeneous with respect to phenotypic markers, effector functions and tissue-homing capabilities and are classified as central (TCM) and effector (TEM) memory T cells [6]. TCM are antigen-experienced cells characterized as CD62LhighCCR7high that migrate to peripheral ly...