Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus? A patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 year after transplantation of autologous stem cell islets. These cells were differentiated from inducible pluripotent stem...
T. R. de Bruijn News & Views18 Sept 2024 Nature Biotechnology P: 1-2 Dedifferentiating myoblasts back into a satellite cell state in vitro Satellite cells, the stem cells of skeletal muscle, are responsible for muscle development and regeneration. Although low in abundance, satellite cells...
Maintenance of long-lasting immunity is thought to depend on stem cell memory T cells (TSCM), which have superior self-renewing capacity, longevity and proliferative potential compared with central memory (TCM) or effector (TEFF) T cells. Our knowledge of TSCMderives primarily from studies of vir...
(4月10日Nature“How to supercharge cancer-fighting cells: give them stem-cell skills”) CAR T细胞 CAR T细胞(Chimeric Antigen Receptor T cells)是一种通过基因工程改造的T细胞,它们被设计用来识别并杀死癌细胞。这种细胞通过从患者体内提取T细...
Bergeles' team has created a working model of an operating room equipped with a robotic arm that can translate the movement of a surgeon. For the moment, they operate only on mannequins but one day they hope to be able to be restoring sight one cell at a time.RELATED...
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The ...
Niethamer研究团队合作在Cell Stem Cell杂志发表题为Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states的研究论文,该研究使用单细胞 RNA 测序和谱系追踪技术,详细分析了流感病毒感染后小鼠肺脏中不同细胞类型的转录组和增殖动态。 打开网易新闻 ...
Since the cancer stem cell concept has been widely accepted, several strategies have been proposed to attack cancer stem cells (CSC). Accordingly, stem cell markers are now preferred therapeutic targets. However, the problem of tumor specificity has not disappeared but shifted to another question: ...
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype Basal-like breast cancer is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. Here the authors provide evidence that ID4 is a key controller of...
Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer...