T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum are short-lived cells equipped with effector machinery and more quiescent, long-lived cells with heightened proliferative potential and stem cell-like developmental plasticity. The ...
(2) measuring step, the LSC marker gene, suppressing the expression of a gene selected constructed test method, the LSC marker gene from the gene of 2-218 containing as an active ingredient, a substance capable of inhibiting the activity of the translation product of the gene or substance ...
3,4,5,6. These stem-like CD8+T cells express transcription factor Tcf-1 (T cell factor-1) and sustain CD8+response during chronic antigen exposure. Importantly, these
PKH26 is a lipophilic marker that intercalates into the membranes of viable cells and is not transferred between cells. A stem cell-like subpopulation (PKH26+) was identified in NPC cell lines using a label-retention technique [19]. PKH26+ cells were enriched for clonogenicity, sphere forma...
Stem cell treatment Stem cell treatment ✅ more than 70 diseases ✅ Cryobank of blood ✅ Embryonic / Fetal / Mesnchymal cells ☎ (068) 938 03 03
3e). In addition, both TCR 1- and TCR 3-expressing cells upregulated similar levels of the acute activation marker CD69 in an antigen-specific manner (Extended Data Fig. 2a,b). Altogether, these results suggest that NeoAg-specific CD4+ T cells with distinct TCRs behave similarly in vivo...
Doublecortin-Like Kinase 1 Is Elevated Serologically in Pancreatic Ductal Adenocarcinoma and Widely Expressed on Circulating Tumor Cells Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and is upregulated in pancreatic cancer, colorectal cancer, and many other solid tumors....
SOX2 is a marker for stem-like tumor cells in bladder cancer. Stem Cell Rep. 2017;9:429–37. Article CAS Google Scholar Jahnke M, Trowsdale J, Kelly AP. Ubiquitination of HLA-DM by different MARCH family E3 ligases targets different endocytic pathways. J Biol Chem. 2012. https://doi...
or PKH26+CSC populations than the respective non-CSC populations in human breast cancer tissues and cancer cell lines and p97 expression also positively correlated with that of SOX2, another CSC marker. To assess the role of p97 in breast cancers, cancer proliferation, mammosphere, and orthotopic...
An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Nature. 2022;602:156–61. Article CAS PubMed Google Scholar Rahman MJ, Regn D, Bashratyan R, Dai YD. Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice. Diabetes. 2014;63...