While naive Tcf7GFP P14 cells highly expressed Tcf7GFP (Tcf7GFPhi), only 40%–60% of memory P14 cells were Tcf7GFPhi (Figure 1A). The expression of Tcf7GFP versus the classical central memory marker CD62L distinguished 3 main populations of memory cells (Figure S1A), which we analyzed...
Nehete, B. Nehete et al., "Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques," PLoS ONE, vol. 6, no. 5, Article ID e19607, 2011.
Various cells are involved in the establishment and maintenance of the reservoir. Due to its relatively large size, retention of proliferative ability, and long life span, the central memory T (Tcm) cell subset is one of the most significant HIV reservoirs [9,10,11]. In HIV infection, HLA-...
Increased replicative senescence, measured by the senescence marker CD57 [12], have been related with immune recovery [13] and could affect CD4 T cells in both naïve and memory subsets [14]. Apart from repli- cative senescence, skewed maturation of memory CD4 T cells [15] and higher ...
Mice trained in a Morris water maze (an assay of spatial memory) showed increased numbers of IL-4-producing T cells in their meninges (Derecki et al., 2010). Moreover, the use of T-cell-deficient mice or the deletion of IL-4 from T cells was shown to impair spatial memory and ...
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or ‘mixed’ priming of helper T cell subsets in vivo. Here, we developed an experimental framework to probe the idea that the site of pri
Results: BLIMP1-deficiency caused an increase in central memory (CM) T cells and a decrease in effector memory (EM) T cells. There was a decrease in the amount of TIM3 exhaustion marker expression in BLIMP1-deficient T cells; however, there was an increase in PD1 exhaustion marker ...
cells in the TME, T cells were extracted and manually annotated into 7 clusters according to the distinct gene expression patterns of each cluster, including CD4+ naive, Treg, CD4+ exhausted, effect memory T-cell (TEM), CD8+ naive, CD8+ toxic T-cell (TOX) and CD8+ exhausted cells (Fig...
A cell surface marker for neural crest and placodal cells: further evolution in peripheral and central nervous system. 来自 dx.doi.org 喜欢 0 阅读量: 50 作者:M Vincent,JP Thiery 摘要: The recent production of a monoclonal antibody (NC-1) recognizing migrating avian neural crest (NC) cells...
To determine the memory features of CD8+T cells, a memory marker IL7R and two memory CD8+T cell signatures32,33were applied in this study. Of the CD8+T cells, two cell clusters were identified, including GZMH+CD8+T cells and GZMK+CD8+T cells (Fig.1b, c, Supplementary Fig.1a). IL...