Results We observed that the IC50 of tumor cells in response to PPIs was significantly higher than that of normal epithelial cells. PPIs significantly increased the expression of PD-L1 on cell membrane at clinically relevant concentrations. Furthermore, pre-treatment with PPIs appeared...
The important discovery that programmed death ligand 1 (PD-L1) expression on tumor cells inhibits programmed cell death 1 (PD-1) on T cells to escape immune surveillance has opened an era of tumor immunotherapy1,2,3,4. PD-L1 is a type I transmembrane protein5containing an extracellular doma...
immunosuppression, which is characterized by the up-regulated expression of PD-1 proteins in activated T cells, a relatively high level of PD-1 proteins on the membrane of depleted T cells, and highly expressed PD-L1 on the tumour cells membrane in the tumour immunosuppressive microenvironment2,...
The results showed that the addition of PS to the culture medium significantly upregulated, whereas the addition of Sph significantly downregulated, the cell- surface expression of PD-L1. Consistently, western blot analysis showed that the PD-L1 level increased by the PS treatment but decreased by...
The amplification, over-expression or mutation of members of the EGFR family has been demonstrated to play important roles in the pathogenesis and progression of certain aggressive types of cancer [127]. Therefore, the members of the EGFR family are ideal targets for delivering drugs to these ...
These include: (E) high constitutive expression of antioxidants driven by constitutive nuclear localization of the master transcriptional regulator Nrf2; (F) enhanced autophagy; (G) activation of DNA repair following double-stranded breaks; (H) the presence of endogenous protease inhibitors (e.g., ...
We found that treatment with HNP and HNP + Laser, could not only induce the upregulation of IL-12b in NK cells but also down-regulated the expression of IL-6 and IL-10, in comparison with the control groups (Fig. 3D). This suggested that the combination treatment of PTT and HNP...
Expression of PSMA in tumor-associated vasculature predicts poorer survival in patients with hepatocellular carcinoma and is likely associated with PD-L1. Int J Surg Pathol. 2024;32:10668969241226704. Article Google Scholar Lazennec G, Rajarathnam K, Richmond A. CXCR2 chemokine receptor - a ...
The infiltration of CD8+ T cells and the expression of PD-L1 on tumor cells were detected by immunohistochemical experiments. Briefly, the prepared paraffin sections of tumor tissues were dried at 65 °C for 1 h, deparaffinized and rehydrated in xylene and graded alcohol (100%, 95%, ...
High-risk patients presented increased immune checkpoint gene expression. The nomogram revealed robust prognostic accuracy. Additionally, we found that GRINA suppression reduced HCC cell proliferation, colony formation, and metastatic potential. Cells with GRINA knockdown presented mitochondrial abnormalities ...